Nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined degree of polymerization
OwnerAnamarija CURIC, Benjamin-Luca KELLER +2inventors
InventorsAnamarija CURIC, Benjamin-Luca KELLER, Thomas MÜLLER, Jörg ROSENBERG
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Abstract
The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.
Claims31
A nanoparticle comprising:
- (i) one or more than one polymer comprising from 60 to 330 monomeric C1-C10-alkyl cyanoacrylate or C1-C6-alkoxy-C1-C10-alkyl cyanoacrylate constituents, and comprising a dispersity of less than 3.0, and
- (ii) one or more than one cargo compound selected from the group consisting of pharmaceutically active agents, cosmetically active agents and nutritional supplements.
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A method for preparing a polymer having a defined degree of polymerization, the method comprising:
- (i) providing a liquid phase comprising C1-C10-alkyl cyanoacrylate or C1-C6-alkoxy-C1-C10-alkyl cyanoacrylate monomer dissolved in an aprotic water-miscible organic solvent or a mixture of two or more aprotic water-miscible organic solvents, where the liquid phase may moreover comprise one or more than one C1-C3-alkanol;
- (ii) adding one or more than one base selected from the group consisting of a metal hydroxide(s) and a metal alkoxide(s) to the liquid phase, where, in case that the base comprises the metal hydroxide(s) and the liquid phase provided in (i) does not contain any C1-C3-alkanols, the metal hydroxide(s) is/are added in the presence of one or more than one C1-C3-alkanol;
- (iii) allowing an equilibrium of depolymerization and repolymerization processes to establish such that the polymer having a defined degree of polymerization is formed;
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- (iv) quenching the polymerization reaction.
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A method for preparing nanoparticles, the method comprising:
- (a) providing a hydrophobic liquid phase comprising:
- (1) one or more than one polymer comprising from 60 to 330 monomeric C1-C10-alkyl cyanoacrylate or C1-C6-alkoxy-C1-C10-alkyl cyanoacrylate constituents, and comprising a dispersity of less than 3.0, and
- (2) one or more than one cargo compound selected from the group consisting of pharmaceutically active agents, cosmetically active agents and nutritional supplements
- dissolved in a water-immiscible organic solvent or a mixture of two or more water-immiscible organic solvents;
- (b) providing a hydrophilic liquid phase;
- (c) finely dispersing the hydrophobic liquid phase in the hydrophilic liquid phase so as to form an emulsion;
- and
- (d) removing at least part of the organic solvent(s) from the emulsion so as to obtain a suspension of nanoparticles in the hydrophilic solvent.
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Dependencies are inferred from the claim text.