# US 2018/0323050 A1 · Ion integrating and cooling cell for mass spectrometer

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- Number: US 2018/0323050 A1
- Document ID: US20180323050A1
- Status: Published application
- Kind: A1
- Application number: 15/588,158
- Filed: 2017-05-05
- Published: 2018-11-08
- Earliest claimed: 2017-05-05
- Assignees: Thermo Finnigan LLC
- Applicants: Thermo Finnigan LLC
- Inventors: Johnathan Wayne SMITH; John E. P. SYKA
- Web page: https://patentgrep.com/patent/US20180323050A1

## CPC

- H01J 49/0468: {with means for heating or cooling the sample}
- H01J 49/0031: {Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence)}
- H01J 49/0481: {with means for collisional cooling}
- H01J 49/065: {having stacked electrodes, e.g. ring stack, plate stack}
- H01J 49/4215: {Quadrupole mass filters (H01J49/4225 takes precedence)}
- H01J 49/4225: {Multipole linear ion traps, e.g. quadrupoles, hexapoles}
- H01J 49/4235: {Stacked rings or stacked plates}
- H01J 49/009: {Spectrometers having multiple channels, parallel analysis}
- H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H)

## Abstract

A method for operating a mass spectrometer comprises: generating a stream of ions by an ion source; directing the stream of ions into a first one of a pair of ion storage locations and trapping a first portion of the ions therein; directing a packet of ions from the other one of the pair of ion storage locations into an ion cooling cell that damps the kinetic energy of the ions comprising the packet of ions; directing the packet of ions to a mass analyzer of the mass spectrometer for mass analysis thereby; directing the first portion of ions from the first one of the pair of ion storage locations into the ion cooling cell; and directing the first portion of ions to the mass analyzer for mass analysis thereby.

## Claims

### Claim 1

A method for operating a mass spectrometer, comprising:
generating a stream of ions by an ion source;
directing the stream of ions into a first one of a pair of ion storage locations and trapping a first portion of the stream of ions therein;
directing a packet of ions from the other one of the pair of ion storage locations to and through an ion cooling cell that damps the kinetic energy of ions of the packet of ions;
directing the packet of ions from the ion cooling cell to a mass analyzer of the mass spectrometer for mass analysis of the ions of the packet of ions thereby;
directing the first portion of the stream of ions from the first one of the pair of ion storage locations to and through the ion cooling cell; and
directing the first portion of the stream of ions from the ion cooling cell to the mass analyzer for mass analysis of ions of the first portion of the stream of ions thereby.

### Claim 2 (depends on 1)

A method as recited in claim 1, wherein the directing of the packet of ions from the other one of the pair of ion storage locations to and through the ion cooling cell is performed simultaneously with the directing of the stream of ions into the first one of the pair of ion storage locations.

### Claim 3 (depends on 1)

A method as recited in claim 1, further comprising:
directing the stream of ions into the other one of the pair of ion storage locations and trapping a second portion of the stream of ions therein.

### Claim 4 (depends on 3)

A method as recited in claim 3, wherein the directing of the stream of ions into the other one of the pair of ion storage locations is performed simultaneously with the directing of the first portion of the stream of ions from the first one of the pair of ion storage locations to and through the ion cooling cell.

### Claim 5 (depends on 3)

A method as recited in claim 3, wherein each one of the trapping of the first portion of the ions and the trapping of the second portion of the ions is performed by trapping the respective portion of the ions in a respective one of a pair of ion traps, each ion trap comprising a plurality of apertured thin electrodes, each apertured thin electrode comprising an aperture therein.

### Claim 6 (depends on 5)

A method as recited in claim 5, wherein the plurality of apertured thin electrodes are mutually parallel.

### Claim 7 (depends on 3)

A method as recited in claim 3, wherein each one of the trapping of the first portion of the ions and the trapping of the second portion of the ions is performed by trapping the respective portion of the ions in a respective one of a pair of ion traps, each ion trap comprising a multipole apparatus comprising a plurality of rod electrodes.

### Claim 8 (depends on 3)

A method as recited in claim 3, wherein each one of the directing of the stream of ions into the first one of the pair of ion storage locations and the directing of the stream of ions into the other one of the pair of ion storage locations comprises:
causing the stream of ions to pass through a first conduit defined by a plurality of apertures, each aperture disposed in a respective apertured thin electrode of a first plurality of apertured thin electrodes; and
causing the stream of ions to pass into a second conduit defined by a second plurality of apertures, each aperture disposed in a respective apertured thin electrode of a second plurality of apertured thin electrodes, wherein the first and second conduits are non-coaxial.

### Claim 9 (depends on 8)

A method as recited in claim 8, wherein the apertured thin electrodes of the first and second pluralities of apertured electrodes are mutually parallel.

### Claim 10 (depends on 1)

A method as recited in claim 1, wherein the step of directing the packet of ions from the other one of the pair of ion storage locations to and through the ion cooling cell comprises:
varying a pseudopotential barrier between a first plurality of apertured thin electrodes and a second plurality of apertured thin electrodes such that ions of the ion packet are transferred, in reverse order of their mass-to-charge ratios, from a first ion conduit defined by a first plurality of apertures to a second conduit defined by a second plurality of apertures, wherein each of the first plurality of apertures is disposed within a respective one of the first plurality of apertured thin electrodes and each of the second plurality of apertures is disposed within a respective one of the second plurality of apertured thin electrodes.

### Claim 11 (depends on 8)

A method as recited in claim 8, wherein the apertured thin electrodes of the first and second pluralities of apertured thin electrodes are mutually parallel.

### Claim 12 (depends on 1)

A method as recited in claim 1,
wherein the directing of the packet of ions from the other one of the ion storage locations to and through the ion cooling cell comprises mass-selectively releasing the ions of the packet of ions from said other one of the ion storage locations in reverse order of mass-to-charge ratio over a period of time,
wherein the mass analysis of the ions of the packet of ions is performed in reverse order of mass-to-charge ratio over a second period of time, and
wherein the mass analysis of the ions of the packet of ions over the second period of time is coordinated with the mass-selective releasing of the packet of ions of the first period of time.

### Claim 13

An apparatus, comprising:
a plurality of first apertured thin electrodes disposed in a stacked relationship relative to one another, each first apertured thin electrode comprising a respective plane having a respective first aperture therein, the plurality of first apertures defining a first ion conduit, the first ion conduit defining an ion pathway through a portion of the apparatus, said ion pathway being transverse to the planes of the first apertured thin electrodes;
a plurality of second apertured thin electrodes disposed in a stacked relationship relative to one another, each second apertured thin electrode comprising a respective plane having a respective second aperture therein, the plurality of second apertures defining a second ion conduit, the second ion conduit defining a second ion pathway through a second portion of the apparatus, said second ion pathway being transverse to the planes of the second apertured thin electrodes;
a plurality of third apertured thin electrodes disposed in a stacked relationship relative to one another and disposed between the plurality of first apertured thin electrodes and the plurality of second apertured thin electrodes, each third apertured thin electrode comprising a respective plane having a respective third aperture therein, the plurality of third apertures defining a curved third ion conduit disposed between and non-coaxial with the first and second ion conduits, the third ion conduit defining a third ion pathway through a third portion of the apparatus, said third ion pathway being transverse to the planes of the third apertured thin electrodes;
a plurality of fourth apertured thin electrodes disposed in a stacked relationship relative to one another and disposed between the plurality of first apertured thin electrodes and the plurality of second apertured thin electrodes, each fourth apertured thin electrode comprising a respective plane having a respective fourth aperture therein, the plurality of fourth apertures defining a curved fourth ion conduit disposed between and non-coaxial with the first and second ion conduits, the fourth ion conduit defining a fourth ion pathway through a fourth portion of the apparatus, said fourth ion pathway being transverse to the planes of the fourth apertured thin electrodes; and
an electrical power supply electrically coupled to each apertured thin electrode of the first plurality, second plurality, third plurality and fourth plurality of apertured thin electrodes and configured to apply an oscillatory radio-frequency (RF) voltage and a respective direct-current (DC) voltage to each of said apertured thin electrodes, such that, within each stacked relationship, a phase of the RF voltage applied to each apertured thin electrode differs by π from the phase of each adjacent apertured thin electrode.

### Claim 14 (depends on 13)

An apparatus as recited in claim 13, further comprising an electrically insulating member disposed between the plurality of third apertured thin electrodes and the plurality of fourth apertured thin electrodes.

### Claim 15 (depends on 13)

An apparatus as recited in claim 13, wherein the apertured thin electrodes of the first, second, third and fourth pluralities of apertured thin electrodes are mutually parallel.

### Claim 16 (depends on 13)

An apparatus as recited in claim 13, wherein the electrical power supply is further configured to apply an auxiliary RF voltage to at least a portion of the third apertured thin electrodes and to at least a portion of the fourth apertured thin electrodes, wherein a same auxiliary RF amplitude, a same auxiliary RF frequency and a same auxiliary RF phase is applied to all apertured thin electrodes of the at least a portion of the third apertured thin electrodes and the at least a portion of the fourth apertured thin electrodes.

### Claim 17 (depends on 13)

An apparatus as recited in claim 13, wherein diameters of apertures of a portion of the plurality of second apertured thin electrodes progressively decrease in a direction away from the third and fourth ion conduits.

### Claim 18 (depends on 17)

An apparatus as recited in claim 17, further comprising:
another portion of the plurality of second apertured thin electrodes; and
a gas supply tube fluidically coupled to the apertures of the other portion of the plurality of second apertured thin electrodes.

### Claim 19 (depends on 13)

An apparatus as recited in claim 13,
wherein the first ion conduit comprises a first end that is an ion inlet of the apparatus and a second end,
wherein the second ion conduit comprises a first end and a second end, the second end being an ion outlet of the apparatus,
wherein each of the first and second ion conduits comprises a respective first end and a respective second end,
wherein the second end of the first ion conduit merges with the first ends of the third and fourth ion conduits, and
wherein the first end of the second ion conduit merges with the second ends of the third and fourth ion conduits.

### Claim 20 (depends on 1)

A method for operating a mass spectrometer as recited in claim 1,
wherein the directing of the stream of ions into the first one of the pair of ion storage locations comprises directing the stream of ions into the first one of the pair of ion storage locations through a switchable branched ion guide, and
wherein the directing of the first portion of the stream of ions from the first one of the pair of ion storage locations to the ion cooling cell comprises directing the first portion of the stream of ions to the ion cooling cell through a second switchable branched ion guide.