# US 2018/0321197 A1 · Suppressor device

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- Number: US 2018/0321197 A1
- Document ID: US20180321197A1
- Status: Published application
- Kind: A1
- Application number: 16/036,548
- Filed: 2018-07-16
- Published: 2018-11-08
- Earliest claimed: 2012-11-12
- Assignees: Dionex Corporation
- Applicants: Dionex Corporation
- Inventors: Kannan SRINIVASAN; Glenn M. KUSE; Rong LIN; Sheetal BHARDWAJ
- Web page: https://patentgrep.com/patent/US20180321197A1

## CPC

- G01N 30/02: Column chromatography
- B01D 15/367: {Ion-suppression}
- G01N 30/92: Construction of the plate
- G01N 30/96: using ion-exchange (G01N30/02, G01N30/90 take precedence)
- B01D 15/36: involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B29K 2071/00: Use of polyethers {, e.g. PEEK, i.e. polyether-etherketone or PEK, i.e. polyetherketone or derivatives thereof}, as moulding material
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- B29K: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR {MOULDS, } REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS

## Abstract

An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel.

## Claims

### Claim 1

A method of suppressing an eluent, the method comprising:
flowing the eluent into a chromatographic column, in which the eluent contains an ionic species;
directing the eluent from the chromatographic column to a primary channel of a suppressor, the suppressor comprising:
a primary channel member including the primary channel through which the eluent including the ionic species flows, the primary channel extending through the primary channel member;
a first block disposed on a first side of the primary channel member and including a first flat surface that faces the primary channel, a first compartment is defined within the first flat surface;
a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block;
a first O-ring disposed within the first compartment and extending around a periphery of the first compartment, the first O-ring forming a seal with the first charged barrier in an assembled state of the suppressor and thereby defining a peripheral shape of a first regenerant channel between the first charged barrier and the first block, the first regenerant channel extending adjacent to the primary channel;
wherein the first O-ring biases the first charged barrier against the primary channel member in the assembled state of the suppressor thereby forming an indirect seal with a first surface of the primary channel member,
a second block disposed on a second side of the primary channel member and including a second flat surface that faces the primary channel, a second compartment is defined within the second flat surface;
a second charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the second charged barrier disposed between the primary channel member and the second block; and
a second O-ring disposed within the second compartment and extending around a periphery of the second compartment, the second O-ring forming a seal with the second charged barrier in the assembled state of the suppressor and thereby defining a peripheral shape of a second regenerant channel between the second charged barrier and the second block, the second regenerant channel extending adjacent to the primary channel,
wherein the second O-ring biases the second charged barrier against the primary channel member in the assembled state of the suppressor thereby forming an indirect seal with a second surface of the primary channel member, the second surface being opposite to the first surface, the method further comprising:
flowing a regenerant through the first regenerant channel and the second regenerant channel;
suppressing the eluent in the primary channel by neutralizing the eluent into a weakly ionized form; and
detecting the ionic species at a conductivity detector.

### Claim 2 (depends on 1)

The method of claim 1, in which the suppressor further comprises a first screen, the first screen disposed within the first regenerant channel.

### Claim 3 (depends on 1)

The method of claim 1, in which the primary channel member is formed of polyether ether ketone (PEEK).

### Claim 4 (depends on 1)

The method of claim 1, in which the first block and the second block are formed of a polymer.

### Claim 5 (depends on 1)

The method of claim 1, in which the first block and the second block are formed of polyether ether ketone (PEEK).

### Claim 6 (depends on 1)

The method of claim 1, in which the first sealing member and the second sealing member are each formed of a material selected from the group consisting of ethylene propylene diene monomer (EPDM) rubbers, thermoplastic elastomers, polypropylene, polytetrafluoroethylene (PTFE), and combinations thereof.

### Claim 7 (depends on 1)

The method of claim 1, in which the first regenerant channel and the second regenerant channel are configured to have a hexagonal shape.

### Claim 8 (depends on 1)

The method of claim 1, in which the first regenerant channel and the second regenerant channel are each configured to include a fluidic area that match a fluidic area of the primary channel.

### Claim 9 (depends on 1)

The method of claim 1, in which the directed eluent from the chromatographic column flows through the primary channel in a first direction, and in which the flowed regenerant through the first regenerant channel and the second regenerant channel flows in a second direction that is opposite to the first direction.

### Claim 10 (depends on 1)

The method of claim 1, in which the primary channel includes an eluent inlet at one end and with an eluent outlet at the other end thereof;
the first regenerant channel includes a first regenerant inlet at one end and with a first regenerant outlet at the other end thereof; and
the second regenerant channel includes a second regenerant inlet at one end and with a second regenerant outlet at the other end thereof,
wherein the eluent inlet and the eluent outlet are independent from the first regenerant inlet and the first regenerant outlet and from the second regenerant inlet and the second regenerant outlet.

### Claim 11 (depends on 1)

The method of claim 1, in which the suppressor comprises a first electrode and a second electrode disposed in the first regenerant channel and the second regenerant channel, respectively.

### Claim 12 (depends on 1)

The method of claim 1, in which the first O-ring directly seals the first regenerant channel and the second O-ring directly seals the second regenerant channel.

### Claim 13 (depends on 11)

The method of claim 11 further comprising:
applying an electrical potential between the first electrode and the second electrode, in which the first electrode produces hydronium ions and an oxygen gas and the second electrode produces hydroxide ions and a hydrogen gas.

### Claim 14 (depends on 1)

The method of claim 1, in which the primary channel member, the first charged barrier, and the first block include coaxial holes for facilitating alignment of the first charged barrier relative to the regenerant channel.