Analyte monitoring systems and methods

A system for determining the level of an analyte in a biological fluid sample from a patient, the system comprising:

• an analyte detection system configured to determine the level of at least one analyte in the biological fluid sample;
• a sample extractor configured to withdraw the biological fluid sample from a patient;
• and
• a sample element comprising:
• a sample cell configured to hold at least one component of the biological fluid sample;
• a sample supply passage in fluid communication with the sample cell;
• and
• a filter disposed in the sample supply passage configured to filter out the at least one component of the sample of bodily fluid;
• wherein the sample cell is configured to receive at least a portion of the biological fluid sample through the sample supply passage, and
• wherein the system is configured to determine the level of an analyte present in the at least one component of the biological fluid sample.