Composition for intraoral delivery of biologically active peptides and proteins

A solid, semi-solid or liquid self-emulsifying composition for intraoral transmucosal delivery of biologically active peptides and proteins, wherein:

• a. the composition spontaneously forms emulsion upon contact with a body fluid or water containing medium;
• b. the composition comprises an oil phase, a surfactant or mixture of surfactants and a physiologically acceptable hydrophobic counter-ion;
• c. said counter-ion forms a salt or a non-covalent complex with peptide or protein;
• d. the formed peptide complex completely dissolved in the composition;
• e. the oil phase of the emulsion contains at least one physiologically acceptable aromatic solubilizing compound which provides complete solubilization of the peptide complex;
• f. upon forming of the emulsion, complex of the counter-ion and biologically active peptide remains entirely associated with the oil droplets of the formed emulsion;
• g. biologically active peptide or protein remains completely dissolved in the oil phase of the formed emulsion.