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US 2018/0305381 A1Published application
Stereoretentive cross-coupling of boronic acids
AssigneeThe Board of Trustees of the University of Illinois
InventorsMartin D. BURKE, Ian CROUCH, Jonathan LEHMANN, Andrea PALAZZOLO, Claire SIMONS
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Abstract
The present disclosure provides tri-orthoalkylphenyl phosphine catalysts that are tuned electrically and sterically. Method of using the catalyst for cross-coupling of unactivated secondary boronic acids with near-perfect levels of site- and stereoretention are also provided.
Claims20
A phosphine compound of Formula I:
- wherein
- A is CH2, C═O, NRA, or O;
- R1 is aryl, heteroaryl, isopropyl, tert-butyl, cycloalkyl, or heterocycloalkyl, wherein aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted;
- R2 is H, (C1-C8)alkyl, (C1-C8)alkoxy, N(RA)2, or an electron withdrawing group;
- and
- each RA is independently H or (C1-C8)alkyl.
3 more elements
Dependencies are inferred from the claim text.