Monoclonal antibodies targeted to human taxilin alpha and methods for use of same

Abstract

A method for diagnosis or aiding in the diagnosis of Sjögren's Syndrome (SS). The diagnosis method requires testing a sample obtained or derived from a subject for an amount of Taxilin alpha, wherein determining an amount of Taxilin alpha that is more than a reference comprises a diagnosis or aids in a diagnosis that the individual has SS, and wherein determining an amount of Taxilin alpha that is the same as or less than a reference indicates the individual does not have SS. A mAb or Taxilin alpha-binding fragment thereof (“Taxilin alpha”) having an antibody heavy chain; an antibody light chain, an antibody comprising a heavy chain and/or an antibody. A kit of the same monoclonal antibody or Taxilin alpha-binding fragment thereof. A method of making the Taxilin alpha. The making method requires separating the Taxilin alpha from a cell culture that expresses the Taxilin alpha.

Dependencies are inferred from the claim text.