Consensus/ancestral immunogens
AssigneesDuke University, University of Alabama at Birmingham Research Foundation, Los Alamos National Security, LLC
InventorsBarton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Abstract
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
Claims24
A recombinant protein comprising the sequence of amino acids set forth in FIG. 14A (SEQ ID NO:
- 13), FIG. 26A (SEQ ID NO:
- 30), or FIG. 29B (SEQ ID NO:
- 36).
(canceled)
A recombinant gp120 envelope protein derived from SEQ ID NO:
- 13, wherein the recombinant gp120 envelope protein comprises an amino acid sequence represented by amino acid numbers 30 to 503 of SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.