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US 2018/0289813 A1Published application
Controlled drug release from electrospun fibers
AssigneeRensselaer Polytechnic Institute
InventorsAnthony R. D'Amato, Nicholas Schaub, Andrew Sante Fiumara, Paul Michael Troiano, Jesus Cardenas, Ryan J. Gilbert
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Abstract
Embodiments of the invention relate generally to electrospun fibers and, more particularly, to the controlled release of an active pharmaceutical ingredient (API) from electrospun fiber scaffolds (EFSs).
Claims20
A controlled-release drug delivery system comprising:
- an electrospun fiber scaffold (EFS) having a polymer crystallinity percentage greater than zero;
- and
- at least one active pharmaceutical ingredient (API),
- wherein the at least one API is released from the EFS upon administration of the drug delivery system to an individual.
1 more element
A drug delivery system comprising:
- a first electrospun fiber scaffold (EFS) having a first crystallinity percentage;
- a second EFS having a second crystallinity percentage different than that of the first EFS;
- and
- at least one active pharmaceutical ingredient (API),
- wherein the at least one API is released from the first EFS at a first rate and the at least one API is released from the second EFS at a second rate different than the first release rate upon administration of the drug delivery system to an individual.
2 more elements
A method of preparing a drug delivery device, the method comprising:
- obtaining a solution including a polymer and at least one active pharmaceutical ingredient (API) dissolved in a solvent;
- electrospinning the solution to obtain an electrospun fiber scaffold (EFS);
- and
- heating the EFS to increase a polymer crystallinity percentage of the EFS.
1 more element
Dependencies are inferred from the claim text.