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US 2018/0282706 A1Published application
New lactaldehyde reductases for the production of 1,2-propanediol
AssigneeMetabolic Explorer
InventorsGwénaëlle CORRE, Pascale ALIPRANDI
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Abstract
The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propane-diol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.
Claims21
A method for producing 1,2-propanediol, comprising the step of converting (R), (S) and/or (R,S) lactaldehyde into 1,2-propanediol with at least one enzyme having one or more of the following properties:
- a) a specific lactaldehyde reductase activity of at least 1850 mU/mg towards (R)-lactaldehyde and NADH in anaerobic conditions,
- b) a specific lactaldehyde reductase activity of at least 600 mU/mg towards (R)-lactaldehyde and NADH in aerobic conditions,
- c) a specific lactaldehyde reductase activity of at least 4350 mU/mg towards (S)-lactaldehyde and NADH in aerobic conditions,
- d) a specific lactaldehyde reductase activity of at least 200 mU/mg towards (R)-lactaldehyde and NADPH, and
- e) a specific lactaldehyde reductase activity of at least 150 mU/mg towards (S)-lactaldehyde and NADPH.
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Dependencies are inferred from the claim text.