Antimicrobial coatings for medical dressings and dry antimicrobial medical dressings therefrom

A dry medical dressing comprising:

• a nonwoven or woven substrate;
• and
• an antimicrobial coating composition dried thereon, the antimicrobial coating composition comprising:
• (i) at least one organosilane (R1O)3Si—R2—Z;
• and
• (ii) at least one amine R9R10R11N,
• wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic;
• and
• wherein the dry medical dressing exhibits residual antimicrobial efficacy against at least one of E. coli, S. aureus, or S. epidermidis.

A method of producing a dry medical dressing, the method comprising:

• saturating a medical dressing with an aqueous composition comprising at least one organosilane (R1O)3Si—R2—Z and at least one amine R9R10R11N;
• and
• drying the medical dressing to produce the dry medical dressing,
• wherein R1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R9, R10, and R11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic;
• and
• wherein the dry medical dressing exhibits residual antimicrobial efficacy against at least one of E. coli, S. aureus, or S. epidermidis.