Method and system for pupillometric assessment of toxin exposure

A pupil size independent method of pupillometry used for assessing exposure toxins in an individual comprising,

• capturing one or more images of a pupil of an individual that is dark adapted;
• determining a pre-stimulus maximum diameter for the pupil of an individual;
• providing a stimulus to the pupil of an individual;
• capturing one or more images of the pupil of an individual following the stimulus;
• timing the pupil's response to the stimulus;
• measuring the extent of the pupil's response to the stimulus;
• determining the onset of constriction for the pupil;
• measuring the minimum constriction value for the pupil;
• characterizing the pupil's response to the stimulus;
• and
• analyzing the pupil's responses to the stimulus to assess exposure to organophosphate (OP) nerve agents or botulinum toxin (BTX) in an individual, wherein the pupil's responses are pupil size independent.