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US 2018/0279927 A1Published application
Enclosed desorption electrospray ionization probes and method of use thereof
AssigneePurdue Research Foundation
InventorsRobert Graham Cooks, Zheng Ouyang, Chien-Hsun Chen, Ziqing Lin, Livia Schiavinato Eberlin
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Abstract
The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
Claims21
1-41. (canceled)
A method for analyzing a tissue section, the method comprising:
- providing a tissue section;
- directing a liquid droplet spray discharge from a desorption electrospray ionization probe onto the thin tissue section, wherein the liquid droplet spray discharge from the desorption electrospray ionization probe desorbs and ionizes an analyte from the tissue section in a manner that preserves the tissue section further analysis;
- transferring the ions of the analyte to a mass spectrometer;
- and
- analyzing the ions of the analyte in the mass spectrometer, thereby analyzing the tissue section.
2 more elements
A method for analyzing a tissue section, the method comprising:
- providing a tissue section;
- directing a liquid droplet spray discharge from a desorption electrospray ionization probe onto the tissue section, wherein the liquid droplet spray discharge from the desorption electrospray ionization probe desorbs and ionizes a lipid from the tissue section in a manner that preserves the tissue section for further analysis;
- transferring the ions of the lipid to a mass spectrometer;
- and
- analyzing the ions of the lipid in the mass spectrometer, thereby analyzing the tissue section.
2 more elements
Dependencies are inferred from the claim text.