Protoporphyrin ix (ppix) imaging
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorJohn V. Frangioni
Life of this patent
Estimating the term…
Abstract
A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remain in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may provide an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide used to capture images. The system may be configured for use in open surgical procedures by providing an operating area that is closed to ambient light.
Claims20
A system comprising:
- a visible light source illuminating a subject, the visible light source providing a range of wavelengths including one or more wavelengths of visible light;
- an excitation light source illuminating the subject, the excitation light source providing an excitation wavelength at approximately 405 nanometers;
- an electronic imaging device that captures image data from a field of view that includes some portion of the subject, the image data including:
- a first image obtained from the one or more wavelengths of visible light, and
- a second image of protoporphyrin IX (PpIX) present in the field of view captured by the electronic imaging device in the near-infrared spectrum;
- and
- a display that renders the first and second images.
A method comprising:
- illuminating a subject, by a visible light source, the visible light source providing a range of wavelengths including one or more wavelengths of visible light;
- illuminating the subject, by an excitation light source, the excitation light source providing an excitation wavelength at approximately 405 nanometers;
- capturing, by an electronic imaging device and from a field of view that includes some portion of the subject, image data that includes:
- a first image obtained from the one or more wavelengths of visible light, and
- a second image of protoporphyrin IX (PpIX) present in the field of view captured by the electronic imaging device in the near-infrared spectrum;
- and
- rendering the first and second images on a display.
A tangible, non-transitory, computer-readable medium storing program instructions that cause an imaging system to execute a process comprising:
- illuminating a subject, by a visible light source of the imaging system, the visible light source providing a range of wavelengths including one or more wavelengths of visible light;
- illuminating the subject, by an excitation light source of the imaging system, the excitation light source providing an excitation wavelength at approximately 405 nanometers;
- capturing, by an electronic imaging device of the imaging system and from a field of view that includes some portion of the subject, image data that includes:
- a first image obtained from the one or more wavelengths of visible light, and
- a second image of protoporphyrin IX (PpIX) present in the field of view captured by the electronic imaging device in the near-infrared spectrum;
- and
- rendering the first and second images on a display.
Dependencies are inferred from the claim text.