Process for the preparation of organic bromides

A process for the preparation of organic bromide of formula (1A) from a carboxylic acid of formula (2A) represented by scheme 1:

• said process comprises radical bromodecarboxylation reaction of carboxylic acid (2A) with a bromoisocyanurate to yield organic bromide (1A);
• wherein
• said bromoisocyanurate is tribromoisocyanuric acid, dibromoisocyanuric acid, bromodichloroisocyanuric acid, dibromochloroisocyanuric acid, bromochloroisocyanuric acid, or any combination thereof;
• A is arene, alkane, cycloalkane or saturated heterocycle;
• n is an integer of at least 1;
• m is an integer of at least 0;
• and
• each Q is independently F, Cl, Br, R1, acyl, C(O)R1, C(O)OR1, C(O)Cl, C(O)N(R1)2, CN, SO2R1, SO3R1, NO2, N(R1)3+, OR1, OCF3, O-acyl, OC(O)R1, OSO2R1, SR1, S-acyl, SC(O)R1, N(R1)acyl, N(R1)C(O)R1, N(R1)SO2R1, N(acyl)2, N[C(O)R1]SO2R1, N[C(O)R1]2, CF3;
• or any two vicinal Q substituents are joined to form a 5- or 6-membered substituted or unsubstituted, saturated or unsaturated carbocyclic or heterocyclic ring;
• wherein each R1 is independently aryl, alkyl, cycloalkyl or heterocyclyl, wherein said R1 is optionally substituted by one or more substituents of R2;
• wherein each R2 is independently F, Cl, Br, COOH, acyl, aryl, alkyl, cycloalkyl or heterocyclyl;
• wherein if either one of R2 in (2A) is carboxylic group COOH, then the respective R2 in (1A) is Br;
• wherein the position of said Br and Q in said structure of formula (1A) correspond to the same position of said COOH and Q, respectively in said structure of formula (2A).