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US 2018/0272011 A1Published application
Mri contrast agent and method for preparing the same
AssigneeHuazhong University of Science and Technology
InventorsQibing ZHOU, Yushuang WEI, Xiangliang YANG
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Abstract
An MRI contrast agent, including superparamagnetic nanoparticles and hydroxyethyl starch. The weight ratio of the superparamagnetic nanoparticles to the hydroxyethyl starch is between 1:5 and 1:15. The superparamagnetic nanoparticles have a particle size of 100-140 nm, and include the following layers, from the inside out, ferrous ferric oxide particles, citric acid, and poly-R-lysine. The citric acid accounts for 6-13 wt. % of the ferrous ferric oxide particles. The poly-R-lysine accounts for 6-20 wt. % of the ferrous ferric oxide particles.
Claims12
A contrast agent, comprising:
- 1) superparamagnetic nanoparticles;
- and
- 2) hydroxyethyl starch;
- wherein:
- a weight ratio of the superparamagnetic nanoparticles to the hydroxyethyl starch is between 1:5 and 1:15;
- the superparamagnetic nanoparticles have a particle size of 100-140 nm, and comprise, from the inside out of the superparamagnetic nanoparticles:
- ferrous ferric oxide particles, citric acid, and poly-R-lysine;
- and
- the citric acid accounts for 6-13 wt. % of the ferrous ferric oxide particles, and the poly-R-lysine accounts for 6-20 wt. % of the ferrous ferric oxide particles.
6 more elements
Dependencies are inferred from the claim text.