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US 2018/0271089 A1Published application
Olfactory ligands
AssigneesUniversity College Cardiff Consultants Limited, Rothamsted Research Limited
InventorsJohn Anthony PICKETT, Michael Alexander BIRKETT, David James MILLER, Rudolf Konrad ALLEMANN
Life of this patent
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Abstract
The invention provides analogues of (S)-germacrene D analogue which have improved insect repellent properties compared to (S)-germacrene D analogue or which have insect attractant properties.
Claims33
A (S)-germacrene D analogue of general formula (I):
- wherein
- R1 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl;
- R2 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl;
- R3 is methyl, ethyl, n-propyl, iso-propyl or cyclopropyl;
- R4 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl;
- R5 is H, methyl, ethyl, n-propyl, iso-propyl or cyclopropyl.
3 more elements
A modified GDS polypeptide comprising a native germacrene D synthase from Solidago canadensis SEQ ID NO:
- 1, which has one or more of the modifications:
- tyrosine residue at position 406 replaced by phenylalanine, leucine, isoleucine, valine or alanine;
- tryptophan residue at position 275 replaced by phenylalanine, leucine, isoleucine, valine or alanine, but especially by phenylalanine;
- tyrosine residue at position 524 replaced by phenylalanine, leucine, isoleucine, valine or alanine, but especially by phenylalanine.
1 more element
(canceled)
Dependencies are inferred from the claim text.