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US 2018/0251765 A1Published application
High-throughput split aptamer screening assay
AssigneeBellbrook Labs, LLC
InventorsMeera Kumar, Robert G. Lowery
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Abstract
Methods and materials for development of high-throughput screening assays using split aptamers are provided by this invention.
Claims28
A sensor for measuring an analyte, comprising:
- (a) a first fragment of a split aptamer and
- (b) a second fragment of the split aptamer;
- wherein the first fragment of the split aptamer comprises a first modification;
- wherein the first fragment of the split aptamer and the second fragment of the split aptamer are associated in the presence of the analyte to form a trimeric complex with the analyte.
1 more element
A sensor for measuring an analyte, comprising:
- (a) a first fragment of a split aptamer and
- (b) a second fragment of a split aptamer;
- wherein the first fragment of the split aptamer is conjugated to a first fragment of a reporter enzyme polypeptide;
- wherein the second fragment of the split aptamer is conjugated to a second fragment of a reporter enzyme polypeptide;
- wherein the first fragment of the split aptamer and the second fragment of the split aptamer are associated in the presence of the analyte to form a trimeric complex with the analyte.
2 more elements
Dependencies are inferred from the claim text.