Back to results
US 2018/0251483 A1Published application
Thiocyanate salts for anti-inflammation
AssigneesNational Jewish Health, Aeolus Pharmaceuticals, Inc.
InventorsBrian J. Day, John McManus
Life of this patent
Estimating the term…
Abstract
Described herein, inter alia, are thiocyanate salt compositions and methods for treating or preventing inflammation using the same.
Claims26
A salt comprising a cationic compound having the structure of Formula (I):
- and an anionic compound having the structure of −SCN;
- wherein
- R1, R2, R3, and R4 are each independently
- R5, R6, R7, R8, R9, and R10 are each independently hydrogen, halogen, —CN, —CF3, —OH, —NH2, —COOH, —COOR12, —CH2COOR12, —CH2COOH, an unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted aryl, or an unsubstituted or substituted heteroaryl;
- R11 is —(CH2)mCH2OX1 or —(CH2CH2O)nX1;
- m is 0-6;
- n is 1-50;
- X1 is substituted or unsubstituted C1-12 alkyl;
- R12 is an unsubstituted alkyl;
- M is a metal;
- and
- each A is, independently hydrogen or an electron withdrawing group.
9 more elements
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.