US 2018/0245118 A1Published application

Production of Activated TDP-Deoxysugars in Recombinant Microorganisms

OwnerMicah Douglas Shepherdinventor

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The invention provides compositions and methods for the production of TDP-deoxysugars.

Dependent claims

A recombinant microorganism comprising:

(a) a functional deletion of rmlC (dTDP-4-dehydrorhamnose 3,5-epimerase), rmlD (dTDP-4-dehydrorhamnose reductase), wecE (TDP-4-oxo-6-deoxy-D-glucose transaminase), and wecD (TDP-fucosamine acetyltransferase);
and
(b) a recombinant polynucleotide encoding rmlA (glucose-1-phosphate thymidylyltransferase), rmlB (dTDP-glucose 4, 6-dehydratase), pgm (phosphoglucomutase), or combinations thereof.

Dependencies are inferred from the claim text.

C12P 19/60
Preparation of O-glycosides, e.g. glucosides: having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a…
A61K 35/66
Medicinal preparations containing materials or reaction products thereof with undetermined constitution: microorganisms or materials therefrom
C12N 9/0006
Oxidoreductases: acting on CH-OH groups as donors
C12N 9/1029
Acyltransferases: transferring groups other than amino-acyl groups

From the US filing history. Foreign family members aren’t listed.

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