Modified Heterocyclase
AssigneesThe University Court of the University of Aberdeen, University Court of the University of St Andrews
InventorsJames NAISMITH, Jesko KOEHNKE, Andrew BENT, Nicholas WESTWOOD, Greg Mann, Wael HOUSSEN IBRAHIM, Marcel JASPARS, Ying GE
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Abstract
This invention relates to an engineered leader-independent heterocyclase (also known as a cyclodehydratase) comprising a defined cyanobactin leader sequence which drives the efficient conversion of heterocyclisable amino acids, such as Ser, Thr and Cys, within a peptide substrate lacking a leader sequence into heterocycles produce a homogenous heterocycle-containing product. This may be useful in biotechnology and chemical synthesis.
Claims27
A modified heterocyclase comprising a cyanobactin leader sequence and a heterocyclase sequence, wherein the cyanobactin leader sequence consists of SEQ ID NO:
- 29 or SEQ ID NO:
- 30.
-3. (canceled)
(canceled)
(canceled)
-17. (canceled)
-25. (canceled)
-30. (canceled)
-40. (canceled)
Dependencies are inferred from the claim text.