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AssigneeOrig3n, Inc.
InventorsRobin Y. Smith, Marcie A. Glicksman, Nikhat F. Zaidi
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The techniques described herein provide for improved efficiency of iPSC production from biological cells. The approach achieves improved iPSC production efficiency by obtaining a set of cells whose cell cycles are synchronized at a specific, desired cell cycle phase, such as mitotic phase (also referred to as M phase). The efficacy with which such synchronized cells can be transformed into iPSCs is higher than for an arbitrary set of cells that comprises cells at a variety of different stages in their cycles. Accordingly, the approaches described herein allow efficient generation of iPSCs, thereby facilitating myriad technologies for personalized and regenerative medicine that rely upon the effective production of iPSCs.
A method of generating a plurality of induced pluripotent stem cells (iPSCs) from a sample comprising a plurality of biological cells, the method comprising:
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