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US 2018/0245038 A1Published application
Method for generating somatic stem cells
OwnerStefano PICCOLO, Luca AZZOLIN +4inventors
InventorsStefano PICCOLO, Luca AZZOLIN, Tito PANCIERA, Michelangelo CORDENONSI, Francesca ZANCONATO, Atsushi FUJIMURA
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Abstract
The present invention provides a method for generating somatic stem cells out of differentiated cells, somatic stem cells obtained by this method and a vector or composition for use in this method.
Claims22
A method for generating somatic stem cells, comprising the steps of:
- a. providing at least one differentiated cell, committed progenitor or partially differentiated cell;
- b. inducing an increased expression or activity of a YAP protein, and/or a TAZ protein, and/or a functional fragment of the YAP and/or the TAZ protein, and/or an activated version of the YAP and/or the TAZ protein, or derivatives thereof in at least one differentiated cell or committed progenitor or partially differentiated cell;
- c. generating a somatic stem cell out of said differentiated cell, committed progenitor or partially differentiated cell.
Dependencies are inferred from the claim text.