Peptide-based synthetic molecules and silica nanostructures
AssigneeMassachusetts Institute of Technology
InventorsANDREA KIMI WALLACE, Maiko Furubayashi, Christopher A. Voigt
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Abstract
Described herein are novel synthetic molecules, polymers, and compositions comprising silica-binding peptides, and their methods of production. Also described herein are methods of synthesizing structurally and chemically complex silica-based materials using the synthetic molecules, polymers, and compositions.
Claims26
A synthetic molecule comprising or consisting essentially of the amino acid sequence of a silica-binding peptide, wherein at least one amino acid of the silica-binding peptide contains at least one non-native post-translational modification.
-3. (canceled)
-18. (canceled)
A synthetic molecule comprising the amino acid sequence of a silica-binding peptide and at least one terminal fusion molecule, wherein each of the at least one terminal fusion molecules is fused to at least one terminal end of the amino acid sequence comprising the amino acid sequence of the silica-binding peptide and optionally wherein:
- at least one of the at least one terminal fusion molecules is a polypeptide selected from the group consisting of Mms6, MamC, CNT1, and CNT2;
- and/or
- the amino acid sequence of the silica-binding peptide comprises the amino acid sequence of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, or SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, SEQ ID NO:
- 25, SEQ ID NO:
- 26, SEQ ID NO:
- 27, SEQ ID NO:
- 28, SEQ ID NO:
- 29, SEQ ID NO:
- 30, SEQ ID NO:
- 31, SEQ ID NO:
- 32, SEQ ID NO:
- 33, or SEQ ID NO:
- 34, and/or a functional variant, thereof.
-22. (canceled)
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-42. (canceled)
-46. (canceled)
-51. (canceled)
-66. (canceled)
-75. (canceled)
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A silica coated DNA-nanostructure comprising silica, R5 peptide, and DNA.
-82. (canceled)
Dependencies are inferred from the claim text.