Monosulfonic phenyltetrazole compounds with applications
AssigneeHangzhou Jennifer Biotech Co., Ltd.
InventorsBenfang Helen RUAN, Jennifer Jin RUAN
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Abstract
A class of compounds of monosulfonic phenyltetrazole, with the structure of 2-(R1 phenyl)-5 (2-sulfonic phenyl)-2H-tetrazole. The 2-sulfonic phenyl tetrazolium salt of this invention has advantages of low toxicity, short synthetic route, easy control of purity and quality. As the 2-sulfonic phenyl tetrazolium salts has almost no absorption at 450 nm where the reduzate has greater absorption, spectrophotometry can simply and rapidly determine the activity of glutamate dehydrogenase, or the content of NADH/NADPH.
Claims12
A composition of Monosulfonic phenyltetrazole compounds comprising a general formula I:
- wherein:
- R1, R2, R3 and R4 are each independently selected from substituent W or H, wherein substituent W comprises 1-50 atoms group selected from C, H, N, O, S, P, Si and a halogen.
4-5. (canceled)
7-8. (canceled)
A composition of Monosulfonic phenyltetrazole compounds comprising a general formula II:
- wherein:
- R1 is substituent X1 unsubstituted, or substituent X1 substituted with one or more substitutable substituent X2 independently, wherein substituent X1 and/or substituent X2 are selected optionally from the following substituted or unsubstituted groups:
- phenyl, nitro, sulfonic group, sulfonamide, a halogen, alkoxy, alkyl, 6-membered heterocycloalkyl group containing 1 or 2 N atoms, 5-membered heterocycloalkyl group containing 1 or 2 heteroatoms each independently selected from N, S, O, bicyclic heteroaryl groups containing 1 or 2 heteroatoms selected from N, S, O;
- R2, R3 and R4 are each independently selected from substituent Y or H, wherein substituent Y is optionally selected from the following groups:
- substituted or unsubstituted alkyl, alkoxy, nitro, halogen atom, azo, phenyl, substituted sulfonic group, heterocyclic alkyl containing 1 N substituent, cycloalkyl.
Dependencies are inferred from the claim text.