Farnesoid x receptor agonists and uses thereof

A compound that has the structure of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:

• wherein,
• R1 and R2 are each independently selected from H, D, F, C1-C4alkyl, or C1-C4fluoroalkyl;
• or R1 and R2 are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted C3-C10cycloalkyl, or substituted or unsubstituted C2-C10heterocycloalkyl;
• or R1 and R2 are taken together with the carbon atom to which they are attached to form a carbonyl (C═O);
• R3 is selected from substituted or unsubstituted C1-C10alkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C2-C10alkynyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein if R3 is substituted then R3 is substituted with one or more R12 groups;
• each R12 is independently selected from D, halogen, —CN, —NO2, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —S(═O)2N(R10)2, —NR10S(═O)2R11, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10fluoroalkyl, unsubstituted or substituted C2-C10alkenyl, unsubstituted or substituted C2-C10alkynyl, unsubstituted or substituted C1-C10heteroalkyl, unsubstituted or substituted C3-C10cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and -L4-L5-R13;
• L4 is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —NR10—, —C(═O)—, —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —OC(═O)—, —OC(═O)NH—, —NHC(═O)NH—, —NHC(═O)O—, —(CH2)r—, or —(OCH2CH2)r—, r is 1, 2, 3, or 4;
• L5 is absent, unsubstituted or substituted C1-C10alkylene, unsubstituted or substituted C1-C10heteroalkylene, unsubstituted or substituted C2-C10alkenylene, unsubstituted or substituted C2-C10alkynylene, unsubstituted or substituted C3-C10cycloalkylene, unsubstituted or substituted C2-C10heterocycloalkylene, unsubstituted or substituted arylene, or unsubstituted or substituted heteroarylene;
• R13 is H, halogen, —N(R10)2, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10alkenyl, unsubstituted or substituted C1-C10alkynyl, unsubstituted or substituted C1-C10cycloalkyl, unsubstituted or substituted C1-C10heterocycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl;
• R4 is -L3-Y;
• L3 is —C(R5)(R6)—, —C(R5)(R6)—C(R7)(R8)—, —C≡C—, —O—C(R7)(R8)—, or —C(R5)(R6)—O—;
• R5 and R7 are each independently selected from H, D, C1-C4alkyl and C3-C6cycloalkyl;
• or R5 and R7 are taken together with the intervening atoms to form a double bond;
• or R5 and R7 are taken together with the intervening atoms to form an epoxide or an substituted or unsubstituted C3-C6cycloalkyl;
• R6 and R8 are each independently selected from H, D, C1-C4alkyl or C3-C6cycloalkyl;
• Y is —CH2OR9, —C(═O)OR9,
• R9 is selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, or substituted or substituted or unsubstituted heterocycle;
• L1 is —X1-L2-, -L2-X1—;
• X1 is —O—, —S—, —S(═O)—, —S(═O)2—, —S(═O)2NR10—, —CH2—, —C≡C—, —C(═O)—, —C(═O)O—, —OC(═O)—, —OC(═O)O—, —C(═O)NR10—, —NR10C(═O)—, —OC(═O)NR10—, —NR10C(═O)O—, —NR10C(═O)NR10—, —NR10S(═O)2—, or —NR10—;
• L2 is absent or substituted or unsubstituted C1-C4alkylene;
• A is CRA, or N;
• each RA is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl;
• B is CRB, or N;
• each RB is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —N(R10)2, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl;
• ring C is monocyclic carbocycle, bicyclic carbocycle, monocyclic N-containing heterocycle, or bicyclic heterocycle;
• each RC is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —NO2, —N(R10)2, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted phenyl and substituted or unsubstituted monocyclic heteroaryl;
• each R10 is independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• or two R10 on the same N atom are taken together with the N atom to which they are attached to form a N-containing heterocycle;
• each R11 is independently selected from substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• m is 0, 1, or 2;
• n is 0, 1, or 2;
• p is 0, 1, 2, 3, or 4.

A compound that has the structure of Formula (IV), or a pharmaceutically acceptable salt or solvate thereof:

• wherein
• R1 and R2 are each independently selected from H, D, F, C1-C4alkyl, or C1-C4fluoroalkyl;
• or R1 and R2 are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted C3-C10cycloalkyl, or substituted or unsubstituted C2-C10heterocycloalkyl;
• or R1 and R2 are taken together with the carbon atom to which they are attached to form a carbonyl (C═O);
• R3 is selected from substituted or unsubstituted C1-C10alkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C2-C10alkynyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein if R3 is substituted then R3 is substituted with one or more R12 groups;
• each R12 is independently selected from D, halogen, —CN, —NO2, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —S(═O)2N(R10)2, —NR10S(═O)2R11, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10fluoroalkyl, unsubstituted or substituted C2-C10alkenyl, unsubstituted or substituted C2-C10alkynyl, unsubstituted or substituted C1-C10heteroalkyl, unsubstituted or substituted C3-C10cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and -L4-L5-R13;
• L4 is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —NR10—, —C(═O)—, —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —OC(═O)—, —OC(═O)NH—, —NHC(═O)NH—, —NHC(═O)O—, —(CH2)r—, or —(OCH2CH2)r—, r is 1, 2, 3, or 4;
• L5 is absent, unsubstituted or substituted C1-C10alkylene, unsubstituted or substituted C1-C10heteroalkylene, unsubstituted or substituted C2-C10alkenylene, unsubstituted or substituted C2-C10alkynylene, unsubstituted or substituted C3-C10cycloalkylene, unsubstituted or substituted C2-C10heterocycloalkylene, unsubstituted or substituted arylene, or unsubstituted or substituted heteroarylene;
• R13 is H, halogen, —N(R10)2, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10alkenyl, unsubstituted or substituted C1-C10alkynyl, unsubstituted or substituted C1-C10cycloalkyl, unsubstituted or substituted C1-C10heterocycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl;
• R4 is -L3-Y;
• L3 is —C(R5)(R6)—, —C(R5)(R6)—C(R7)(R8)—, —C≡C—, —O—C(R7)(R8)—, or —C(R5)(R6)—O—;
• R5 and R7 are each independently selected from H, D, C1-C4alkyl and C3-C6cycloalkyl;
• or R5 and R7 are taken together with the intervening atoms to form a double bond;
• or R5 and R7 are taken together with the intervening atoms to form an epoxide or an substituted or unsubstituted C3-C6cycloalkyl;
• R6 and R8 are each independently selected from H, D, C1-C4alkyl or C3-C6cycloalkyl;
• Y is —CH2OR9, —C(═O)OR9,
• R9 is selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, or substituted or substituted or unsubstituted heterocycle;
• each RA is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl;
• B is CRB, or N;
• each RB is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —N(R10)2, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl;
• ring C is a 5-membered N-containing heteroaryl, or a N-containing C2-C8heterocycloalkyl;
• each RC is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —NO2, —N(R10)2, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted phenyl and substituted or unsubstituted monocyclic heteroaryl;
• each R10 is independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• or two R10 on the same N atom are taken together with the N atom to which they are attached to form a N-containing heterocycle;
• each R11 is independently selected from substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• m is 0, 1, or 2;
• n is 0, 1, or 2;
• p is 0, 1, 2, 3, or 4.

A compound that has the structure of Formula (VI), or a pharmaceutically acceptable salt or solvate thereof:

• wherein
• R1 and R2 are each independently selected from H, D, F, C1-C4alkyl, or C1-C4fluoroalkyl;
• or R1 and R2 are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted C3-C10cycloalkyl, or substituted or unsubstituted C2-C10heterocycloalkyl;
• or R1 and R2 are taken together with the carbon atom to which they are attached to form a carbonyl (C═O);
• R3 is selected from substituted or unsubstituted C1-C10alkyl, substituted or unsubstituted C2-C10alkenyl, substituted or unsubstituted C2-C10alkynyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein if R3 is substituted then R3 is substituted with one or more R12 groups;
• each R12 is independently selected from D, halogen, —CN, —NO2, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —S(═O)2N(R10)2, —NR10S(═O)2R11, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —N(R10)2, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10fluoroalkyl, unsubstituted or substituted C2-C10alkenyl, unsubstituted or substituted C2-C10alkynyl, unsubstituted or substituted C1-C10heteroalkyl, unsubstituted or substituted C3-C10cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and -L5-L6-R13;
• L5 is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —NR10—, —C(═O)—, —C(═O)NH—, —NHC(═O)—, —C(═O)O—, —OC(═O)—, —OC(═O)NH—, —NHC(═O)NH—, —NHC(═O)O—, —(CH2)r—, or —(OCH2CH2)r—, r is 1, 2, 3, or 4;
• L6 is absent, unsubstituted or substituted C1-C10alkylene, unsubstituted or substituted C1-C10heteroalkylene, unsubstituted or substituted C2-C10alkenylene, unsubstituted or substituted C2-C10alkynylene, unsubstituted or substituted C3-C10cycloalkylene, unsubstituted or substituted C2-C10heterocycloalkylene, unsubstituted or substituted arylene, or unsubstituted or substituted heteroarylene;
• R13 is H, halogen, —N(R10)2, unsubstituted or substituted C1-C10alkyl, unsubstituted or substituted C1-C10alkenyl, unsubstituted or substituted C1-C10alkynyl, unsubstituted or substituted C1-C10cycloalkyl, unsubstituted or substituted C1-C10heterocycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl;
• ring A is a monocyclic carbocycle, monocyclic heterocycle, or bicyclic heterocycle;
• each RA is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl;
• L1 is —X1-L2-, or -L2-X1—;
• X1 is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —S(═O)2NR10—, —CH2—, —CH═CH—, —C≡C—, —C(═O)—, —C(═O)O—, —OC(═O)—, —OC(═O)O—, —C(═O)NR10—, —NR10C(═O)—, —OC(═O)NR10—, —NR10C(═O)O—, —NR10C(═O)NR10—, —NR10S(═O)2—, or —NR10—;
• L2 is absent or substituted or unsubstituted C1-C4alkylene;
• ring C is monocyclic carbocycle, bicyclic carbocycle, monocyclic heterocycle, or bicyclic heterocycle;
• each RC is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —NO2, —N(R10)2, —S(═O)2R11, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted phenyl and substituted or unsubstituted monocyclic heteroaryl;
• ring B is a monocyclic carbocycle, bicyclic carbocycle, monocyclic heterocycle or bicyclic heterocycle;
• each RB is independently selected from H, D, halogen, —CN, —OH, —OR10, —SR10, —S(═O)R11, —S(═O)2R11, —N(R10)2, —NHS(═O)2R11, —S(═O)2N(R10)2, —C(═O)R11, —OC(═O)R11, —CO2R10, —OCO2R11, —C(═O)N(R10)2, —OC(═O)N(R10)2, —NR10C(═O)N(R10)2, —NR10C(═O)R11, —NR10C(═O)OR11, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C2-C6alkynyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl;
• R5 and R7 are each independently selected from H, D, C1-C4alkyl and C3-C6cycloalkyl;
• or R5 and R7 are taken together with the intervening atoms to form a double bond;
• or R5 and R7 are taken together with the intervening atoms to form an epoxide or an substituted or unsubstituted C3-C6cycloalkyl;
• R6 and R8 are each independently selected from H, D, C1-C4alkyl or C3-C6cycloalkyl;
• Y is —CH2OR9, —C(═O)OR9, —CH2C(═O)OR9,
• each R9 is independently selected from H, substituted or unsubstituted C2-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C2-C6alkenyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, and substituted or substituted or unsubstituted heterocycle;
• each R10 is independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• or two R10 on the same N atom are taken together with the N atom to which they are attached to form a N-containing heterocycle;
• each R11 is independently selected from substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted phenyl, substituted or unsubstituted monocyclic heteroaryl, and substituted or unsubstituted benzyl;
• m is 0, 1, or 2;
• n is 0, 1, or 2;
• p is 0, 1, 2, 3, or 4.

A compound selected from the group consisting of:

• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)pivalamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)butyramido)phenyl)acrylate;
• (E)-Methyl 3-(3-(((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)(ethoxycarbonyl)amino)phenyl)acrylate;
• (E)-Methyl 3-(3-(4-cyano-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)benzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)tetrahydro-2H-pyran-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)oxetane-3-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-3,3-dimethylbutanamido)phenyl)acrylate;
• (E)-Methyl 3-(3-((1r,4r)-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-methoxycyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-((1s,4s)-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-methoxycyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-methoxybenzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cycloheptanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)adamantane-1-carboxamido)phenyl)acrylate;
• (E)-methyl 3-(3-(N-(4-cyclohexylbenzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-3,4-difluorobenzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-fluorobenzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-1-methylcyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-fluorophenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)bicyclo[2.2.1]heptane-2-carboxamido)-5-fluorophenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-methyltetrahydro-2H-pyran-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-2-methoxybenzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-1,1-dioxidotetrahydro-2H-thiopyran-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)tetrahydro-2H-thiopyran-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-3-methoxybenzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-1-(methylsulfonyl)azetidine-3-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(2-morpholinoethoxy)benzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(methylthio)cyclohexanecarboxamido)phenyl)acrylate;
• cis-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(methylsulfonyl)cyclohexanecarboxamido)phenyl)acrylate;
• trans-(E)-methyl 3 -(3 -(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(methylsulfonyl)cyclohexanecarboxamido)phenyl)acrylate;
• trans-4-(((4′-(Dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)(3-((E)-3-methoxy-3-oxoprop-1-en-1-yl)phenyl)carbamoyl)cyclohexanecarboxylic acid;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-6-oxopiperidine-3-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-2-oxopiperidine-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-1-oxidotetrahydro-2H-thiopyran-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(methylsulfinyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-hydroxybenzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(2-hydroxyethoxy)benzamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-3-hydroxy-2,2-dimethylpropanamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(3-chloro-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-2,2-dimethylpropanamido)phenyl)acrylate;
• trans-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-2-hydroxycyclohexanecarboxamido)phenyl)acrylate;
• cis-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-2-hydroxycyclohexanecarboxamido)phenyl)acrylate;
• cis-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-3-hydroxycyclohexanecarboxamido)phenyl)acrylate;
• trans-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-3-hydroxycyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclopentanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclobutanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)amino)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-oxocyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)tetrahydro-2H-pyran-2-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-1,4-dioxane-2-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)tetrahydro-2H-pyran-3-carboxamido)phenyl)acrylate;
• cis-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)phenyl)acrylate;
• trans-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′-methyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(pyridin-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-cyano-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-cyano-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-fluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-fluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′-fluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-pyrazol-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(pyridin-3-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-(trifluoromethoxy)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(3,5-dimethylisoxazol-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-isopropoxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′-fluoro-4′-methoxy-[1,1′-biphenyl]-4-y1)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-chloro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(6-(dimethylamino)pyridin-3-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-methylphenyl)acrylate;
• (E)-Methyl 3-(5-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-4-methylphenyl)acrylate;
• Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)propanoate;
• (E)-N-((4′-(Dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-N-(3-(3-methoxyprop-1-en-1-yl)phenyl)cyclohexanecarboxamide;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)but-2-enoate;
• (E)-Methyl 3-(3-(N-(1-(4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)ethyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-isopropyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(pyrrolidin-1-yl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(1H-indazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-methyl 3-(3-(N-((4′-(dimethylamino)-2-fluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-methyl 3-(3-(N-((4′-(dimethylamino)-3-fluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-2-methyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-3-methyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-hydroxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′-hydroxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-hydroxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-methoxy-4′-methyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′,6′-difluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-((tert-butoxycarbonyl)(methyl)amino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(methylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-indol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)isonicotinamido)phenyl)acrylate;
• (E)-Methyl 4′-((N-(3-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl)cyclohexanecarboxamido)methyl)-[1,1′-biphenyl]-3-carboxylate;
• (E)-Methyl 4′-((N-(3-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl)cyclohexanecarboxamido)methyl)-[1,1′-biphenyl]-4-carboxylate;
• (E)-Methyl 3-(3-(N-((4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-tert-Butyl 4-(((4′-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)(3-(3-methoxy-3-oxoprop-1-en-1-yl)phenyl)carbamoyl)piperidine-1-carboxylate;
• (E)-Methyl 3-(3-(N-((3′-(hydroxymethyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(hydroxymethyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d][1,3]dioxol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-chloro-4′-methoxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2-cyano-4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3-cyano-4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-2-ethyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-3-ethyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)piperidine-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(1-acetyl-N-((4′-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)piperidine-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-methoxy-3′-methyl-[1,1′-biphenyl]-4-yl)methyl)-1-(methylsulfonyl)piperidine-4-carboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)-2-methylacrylate;
• (E)-Methyl 3-(3-(N-((3′-cyano-4′-methoxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(pyridin-2-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′-cyano-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(thiazol-2-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(thiazol-4-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(thiazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-isopropyl-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(prop-1-en-2-yl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-cyano-4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-3′-fluoro-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-methyl 3-(3-(N-((4′-(dimethylamino)-3′-methoxy-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(azetidin-1-yl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(2-(dimethylamino)pyrimidin-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(5-(dimethylamino)pyrazin-2-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(6-(dimethylamino)pyridazin-3-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(N-methylmethylsulfonamido)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-fluoro-4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((2′-fluoro-4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]thiazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((3′-chloro-4′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]oxazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]oxazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]isoxazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]thiazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]isoxazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]isothiazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzo[d]isothiazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(3-fluoro-1-methyl-1H-indazol-5-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(3-methylbenzo[d]isothiazol-6-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(4-methylpiperazin-1-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-morpholinobenzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(piperidin-1-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(piperazin-1-yl)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(naphthalen-1-ylmethyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-([1,1′-biphenyl]-2-ylmethyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-([1,1′-biphenyl]-3-ylmethyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-iso-Propyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Ethyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-ethylphenyl)acrylate;
• (E)-2-Hydroxyethyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Cyclohexyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Isobutyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-2-Methoxyethyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-2-(Dimethylamino)ethyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-(Tetrahydrofuran-2-yl)methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-2,2,2-Trifluoroethyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Benzyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-methoxyphenyl)acrylate;
• (E)-Methyl 3-(3-cyano-5-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-chloro-5-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-(trifluoromethyl)phenyl)acrylate;
• Methyl 3-(3-(N-((4′-(Dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)propiolate;
• (E)-3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylic acid;
• (E)-3-(3-((1s,4s)-N-((4′-(Dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-hydroxycyclohexanecarboxamido)phenyl)acrylic acid;
• Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-5-methylphenyl)propanoate;
• Methyl 3-(5-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)propanoate;
• Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-2-methylphenyl)propanoate;
• Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)-4-methylphenyl)propanoate;
• Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)butanoate;
• Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)-2-methylpropanoate;
• (E)-Methyl 3-(3-(trans-4-((tert-butoxycarbonyl)amino)-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(trans-4-amino-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3 -(trans-N 4(4′ -(di methylamino)-[1,1′-biphenyl]-4-yl)methyl)-4- ((methoxycarbonyl)amino)cyclohexanecarboxamido)phenyl)acrylate;
• trans-(E)-Methyl 3-(3-(4-acetamido-N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate;
• trans-(E)-Methyl 3-(3-(N-((4′-(dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-4-(methylsulfonamido)cyclohexanecarboxamido)phenyl)acrylate;
• N-((4′-(Dimethylamino)-[1,1′-biphenyl]-4-yl)methyl)-N-(3-(3-methylbut-2-en-1-yl)phenyl)cyclohexanecarboxamide;
• (E)-Methyl 3-(3-(N-(4-benzamidobenzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(N-methylbenzamido)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzylamino)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• (E)-Methyl 3-(3-(N-(4-(benzyl(methyl)amino)benzyl)cyclohexanecarboxamido)phenyl)acrylate;
• or a pharmaceutically acceptable salt, or solvate thereof.