PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof
AssigneeMerial Limited
InventorsTeshome Mebatsion, Aemro Kassa, Taejoong Kim
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Abstract
The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.
Claims20
A safe and effective immunological or vaccine composition comprising:
- a. one or more recombinant viral vectors, comprising one or more heterologous polynucleotides, encoding one or more porcine reproductive and respiratory syndrome virus (PRRSV) gp2, gp3, gp4, gp5a, gp5 or E antigen, polypeptide, ectodomain, or variant thereof;
- and
- b. a pharmaceutically or veterinarily acceptable carrier.
A recombinant Ad5-PRRSV vector comprising, consisting essentially of or consisting of one or more polynucleotide encoding one or more PRRSV gp2, gp3, gp4, gp5a, gp5 or E antigen(s), polypeptide(s), ectodomain(s) or variant(s) thereof, or a combination thereof.
A method of eliciting a protective response in an animal in need thereof against PRRSV comprising administering to the animal a recombinant Ad5-PRRSV vector expressing at least one PRRSV gp2, gp3, gp4, gp5a, gp5 or E antigen, polypeptide, ectodomain, or variant thereof, and a pharmaceutically or veterinarily acceptable carrier, adjuvant, excipient or vehicle;
- and/or
- wherein the administration is by oro-nasal, spray, drinking water, intramuscular, or subcutaneous administration, intradermal, transdermal;
- and/or
- wherein the administration is prime-boost;
- and/or
- wherein the first vaccination is a mixture of two Ad5 vectors, the first Ad5 vector expressing re-targeted PRRSV minor proteins and the second Ad5 vector expressing PRRSV major proteins;
- and wherein the boost comprises or consists essentially of either both vectors of the first vaccination, or either vector alone;
- and/or
- wherein the animal is a porcine.
Dependencies are inferred from the claim text.