Proteins used for the diagnosis of lyme borreliosis
AssigneeBiomerieux
InventorsLionel LEVET, Odile MEJAN-LETOURNEUR
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Abstract
Chimera proteins includlng: (i) at least one sequence of a DbpA protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii, and (ii) at least one sequence of an OspC protein of a Borrelia species selected from B. afzelii, B. burgdorferi sensu stricto and B. garinii. Also, a method and a kit for the in vitro diagnosis of Lyme borreliosis using said proteins.
Claims20
A polypeptide comprising (i) a Decorin-binding protein A (DbpA) extracellular domain portion from B. afzelii, B. burgdorferi sensu stricto, or B. garinii that includes DbpA immunodominant epitope regions, and (ii) an Outer-surface protein C (OspC) extracellular domain portion from B. afzelii, B. burgdorferi sensu stricto, or B. garinii that includes OspC immunodominant epitope regions.
A polypeptide comprising (i) a first amino acid sequence having at least 40% sequence identity with any of the amino acid sequences selected from the group consisting of SEQ ID NOs:
- 1, 3, 5, and 6, and (ii) a second amino acid sequence having at least 50% sequence identity with any of the amino acid sequences selected from the group consisting of SEQ ID NOs:
- 2, 4, and 7, wherein the first amino acid sequence and the second amino acid sequence are capable of forming an immunological complex with antibodies produced following a Borrelia infection.
A polypeptide comprising (i) a first amino acid sequence having at least 40% sequence identity with the amino acid sequence of SEQ ID NO:
- 1, and (ii) a second amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO:
- 2, wherein the first amino acid sequence and the second amino acid sequence are capable of forming an immunological complex with antibodies produced following a Borrelia infection.
Dependencies are inferred from the claim text.