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US 2018/0237363 A1Published application
Method for coupling an aromatic compound to an alkyne
AssigneeDow Global Technologies LLC
InventorsPatrick S. Hanley, Matthew J. Jansma, Arkady L. Krasovskiy
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Abstract
In one aspect, there is provided a method of coupling an aromatic compound having a fluorosulfonate substituent to an alkyne. In another aspect, there is provided a method of coupling an aromatic compound having a hydroxyl substituent to an alkyne in a one-pot reaction.
Claims17
A method of coupling an aromatic compound to an alkyne, the method comprising:
- providing the aromatic compound having a fluorosulfonate substituent of the formula —OSO2F;
- providing the alkyne;
- and
- reacting the aromatic compound and the alkyne in a reaction mixture, the reaction mixture including a catalyst comprising one or more of a group 10 atom and a copper complex, the reaction mixture under conditions effective to couple the aromatic compound to the alkyne.
1 more element
A method of coupling an aromatic compound to an alkyne, the method comprising:
- providing the aromatic compound having a hydroxyl substituent;
- providing sulfuryl fluoride in the presence of a base;
- reacting the aromatic compound and the sulfuryl fluoride in a reaction mixture, the reaction mixture under conditions effective to couple the sulfur atom of the sulfuryl fluoride to the oxygen of the hydroxyl group;
- providing to the reaction mixture the alkyne;
- providing to the reaction mixture a catalyst comprising one or more of a copper complex or a group 10 atom;
- and
- reacting the aromatic compound and the alkyne in the reaction mixture, the reaction mixture under conditions effective to couple the aromatic compound to the alkyne.
4 more elements
Dependencies are inferred from the claim text.