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US 2018/0231565 A1Published application
Methods for determining the risk of a systemic lupus erythematosus (sle) patient to develop neuropsychiatric syndromes
AssigneeImmunarray Ltd.
InventorsKeren JAKOBI, Anat REINER-BENAIM
Life of this patent
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Abstract
Methods and kits are provided for diagnosing of neuropsychiatric syndromes concurrent with SLE (NPSLE) and for determining whether an SLE subject is at risk of developing a neuropsychiatric disease.
Claims19
A method of diagnosing neuropsychiatric systemic lupus erythematosus (NPSLE) in a subject, the method comprising the steps of:
- (i) obtaining a sample from the subject;
- (ii) determining the reactivity of antibodies in the sample to at least four antigens selected from the group consisting of ENO1, Sm, Collagen IV, Laminin, Collagen III and FNIII, thereby determining the reactivity pattern of the sample to the plurality of antigens;
- and
- (iii) comparing the reactivity of antibodies in the sample to a reactivity of a non-NPSLE control by a supervised classification algorithm;
- wherein a significantly different reactivity of the antibodies in the sample compared to the reactivity of the non-NPSLE control is an indication that the subject is afflicted with NPSLE.
2 more elements
An antigen probe set comprising the antigen probes ENO1, Sm, Collagen IV, Laminin, Collagen III and FNIII.
A method for classifying a subject as having NPSLE or non-NPSLE, the method comprising the steps of:
- (i) obtaining a sample from the subject;
- (ii) determining the reactivity of antibodies in the sample to at least four antigens selected from the group consisting of ENO1, Sm, Collagen IV, Laminin, Collagen III and FNIII, thereby determining the reactivity pattern of the sample to the plurality of antigens;
- (iii) calculating a score based on the reactivity of antibodies in the sample by a supervised classification algorithm and comparing said score to a pre-determined threshold level;
- wherein a significantly different reactivity of the antibodies in the sample with a score above the pre-determined threshold level, is an indication that the subject is afflicted with NPSLE.
1 more element
Dependencies are inferred from the claim text.