Composition for use in treating and preventing inflammation related disorder
AssigneeAihol Corporation
InventorShyh-Shyan Lin
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AssigneeAihol Corporation
InventorShyh-Shyan Lin
Estimating the term…
The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (HA) or HA mixture, whereas the HA or the HA mixture as a delivery vehicle can be a formulation including at least two HAs having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (GERD), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (IBD), Crohn's Disease, irritable bowel syndrome (IBS), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis.
A composition for use in treating or preventing an inflammation and/or allergy related disorder in a mammal or human comprising a drug suitable for the treatment of an inflammation and/or allergy and a hyaluronic acid (HA) mixture, wherein the HA mixture comprises at least two hyaluronic acids including low average molecular weight HA (LMWHA) and high average molecular weight HA (HMWHA), wherein the average Mw of the LMWHA is between 50 kilo Da and 1.5 million Da, and the average Mw of the HMWHA is between 1.5 million Da and 5 million Da, wherein the LMWHA and the HMWHA are apart from each other by at least 0.5 million Da, and a mixing ratio of the LMWHA and the HMWHA is in a range from 20:80 to 80:20 by weight.
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