Methods for reducing proteotoxicity
AssigneeThe Regents of the University of California
InventorsAndrew Dillin, Hyun-Eui Kim
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Abstract
The present disclosure provides methods of reducing protein misfolding and/or aggregation in a cell. The present disclosure provides methods of treating diseases and disorders associated with protein misfolding and/or aggregation.
Claims20
A method of reducing protein aggregation and/or protein misfolding in a cell, the method comprising contacting the cell with an agent that modulates a mitochondrial to cytosolic stress response in the cell.
A method of treating a disease or disorder associated with protein misfolding and/or aggregation in an individual, the method comprising administering to the individual an effective amount of an agent that modulates a mitochondrial to cytosolic stress response in the cell.
Dependencies are inferred from the claim text.