Inverse Ugelstad Particles
AssigneeSintef
InventorsGeir FONNUM, Nils LUNDBERG, Muhammed GOKMEN, Synne LARSEN, Wilhelm Glomm, Heidi Johnsen, Ruth SCHMID, Lars Kilaas
Life of this patent
Estimating the term…
Abstract
This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
Claims25
Monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from
- (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 1;
- and
- (b) a crosslinker comprising at least two vinyl groups.
-21. (canceled)
(canceled)
-39. (canceled)
A method of forming monodisperse seed particles comprising:
- dissolving N,N-dimethylacrylamide, a stabilizer, a radical initiator and a chain transfer agent in an organic solvent to form a reaction mixture;
- and
- heating the reaction mixture to activate the initiator,
- thereby forming the monodisperse seed particles.
-55. (canceled)
A method of forming monodisperse crosslinked hydrogel polymer particles comprising:
- forming a solution (a) of at least 2% wt of a hydrophilic vinylic monomer in an aqueous solution, the solution also comprising a crosslinker comprising at least two vinyl groups;
- forming a solution (b) of stabilizer in an organic solvent, wherein the organic solvent is not miscible in water, and wherein at least one of solution (a) and solution (b) comprises a radical initiator;
- mixing solutions (a) and (b) to form a water-in-oil emulsion (c) and adding monodisperse seed particles to the emulsion;
- allowing the monodisperse seed particles to form swollen particles in the emulsion;
- and
- polymerising the swollen particles to form the monodisperse crosslinked hydrogel polymer particles.
-122. (canceled)
Dependencies are inferred from the claim text.