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US 2018/0208920 A1Published application
Molecular machines
OwnerColin SCOTT, Carol HARTLEY +5inventors
InventorsColin SCOTT, Carol HARTLEY, Charlotte WILLIAMS, Quentin CHURCHES, Judith SCOBLE, Nicholas TURNER, Nigel FRENCH
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Abstract
The present disclosure relates to isolated enzyme complexes comprising a tethered cofactor and at least two enzymes paired to catalyse an enzymatic reaction and recycle the cofactor.
Claims38
An isolated enzyme complex comprising;
- a) a cofactor,
- b) a first enzyme that requires the cofactor to perform an enzymatic reaction, and
- c) a second enzyme that recycles the cofactor,
- wherein the first enzyme, second enzyme and cofactor form the enzyme complex through covalent attachments, and wherein the cofactor is covalently attached via a tether that allows the cofactor to be used by the first enzyme and recycled by the second enzyme.
1 more element
The enzyme complex of claim 21 or claim 22, wherein the linker is a linker as defined in any one of claims 11 to 14.
The method according to any one of claims 28 to 32, wherein the host cell is a bacterial cell, a yeast cell, a plant cell or an animal cell.
Dependencies are inferred from the claim text.