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US 2018/0201966 A1Published application
Method for the synthesis of pentostatin
OwnerOleksandr Zabudkin, Christian Schickaneder +2inventors
InventorsOleksandr Zabudkin, Christian Schickaneder, Iaroslav Matviienko, Volodymyr Sypchenko
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Abstract
The present invention relates to a method for the stereo-selective production of pentostatin comprising an enzymatic transglycosylation reaction between 6,7-dihydroimidazo-[4,5-d]-[1,3]diazepin-8(3H)-one and a 2′-deoxyribonucleoside, followed by an ruthenium-catalyzed asymmetric transfer hydrogenation.
Claims18
Method for the stereo-selective synthesis of the pentostatin, comprising:
- (i) reacting 6,7-dihydroimidazo-[4,5-d]-[1,3]diazepin-8(3H)-one and a 2-deoxy-ribonucleoside;
- and
- (ii) reducing the 8-keto pentostatin derivative obtained in step (i) by ruthenium-catalyzed asymmetric transfer hydrogenation;
- wherein the reaction in step (i) is enzymatically catalyzed by nucleoside deoxyribosyltransferase.
1 more element
Dependencies are inferred from the claim text.