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US 2018/0201962 A1Published application
Generation of acyl alcohols
AssigneeModular Genetics, Inc.
InventorKevin A. Jarrell
Life of this patent
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Abstract
Methods, compositions, and cells for generating acyl alcohols. Compositions comprising acyl alcohols. Methods of cleaving acyl amino acids and/or acyl alcohols to generate free fatty acids, free amino acids, and/or free alcohols.
Claims42
A method comprising steps of:
- providing an acyl amino acid;
- and
- treating the acyl amino acid with a reductase polypeptide so that an acyl alcohol is released.
A method comprising steps of
- providing an acyl amino acid and/or acyl alcohol;
- and
- treating the acyl amino acid or acyl alcohol so that i) free fatty acid and ii) free amino acid and/or free alcohol is released.
A composition comprising an acyl alcohol comprising a fatty acid covalently and directly linked to an alcohol.
A composition comprising an acyl alcohol and one or more components of an engineered microbial cell.
An engineered microbial cell comprising one or more polypeptides collectively comprising:
- a fatty acid linkage domain, a peptide synthetase domain, and one or more reductase polypeptides,
- which fatty acid linkage domain is covalently linked to the peptide synthetase domain,
- which fatty acid linkage domain and peptide synthetase domain collectively can produce an acyl amino acid,
- and which one or more reductase polypeptides are collectively capable of reducing the acyl amino acid to an acyl alcohol.
1 more element
Dependencies are inferred from the claim text.