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US 2018/0201894 A1Published application
Heatseal Sampling
AssigneeGeneral Electric Company
InventorsManoj RAMAKRISHNA, Haresh Digambar PATIL, Sebastian JOHN
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Abstract
The present invention provides a device and method for sampling from a cell culture bioreactor. The invention is useful where it is required to determine the cell count, provide a sample for off-line analyses or remove a sample while at the same time retain sterility of the sample for quality control (QC) assessment. The device of the invention allows for facile aseptic sampling at one or more instances in time during a cell expansion in a bioreactor.
Claims22
A device for taking a sample from a liquid cell culture in a bioreactor wherein said device comprises:
- (i) a hollow body comprising outer walls that define a fluid path therethrough wherein said outer walls are at least partly comprised of a sealable material, wherein said fluid path begins at an upstream end and ends at a downstream end of said hollow body, and wherein said upstream and downstream ends are adapted to fluidly connect said fluid path with the interior of said bioreactor;
- and,
- (ii) a sealing means which is adapted to seal the perimeter of a section of said sealable material without blocking said fluid path, wherein said sealing means is moveable between different portions of said outer walls.
Dependencies are inferred from the claim text.