Vitamin k and capillary function
AssigneeVitak BV
InventorCornelis Vermeer
Life of this patent
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Abstract
A new indication of vitamin K is disclosed which results in the provision of methods of treatment, both therapeutic and non-therapeutic, as well as functional foods and pharmaceutical and nutraceutical products comprising vitamin K for improving microvascular integrity and capillary structure and function, thus preventing, mitigating, counteracting or curing diseases associated with impaired capillary morphology including the glycocalyx or capillary dysfunction. Preferably, vitamin K is a menaquinone, most preferably selected from the long-chain menaquinones MK-7 through MK-10.
Claims11
A method of treatment for improving the exchange of nutrients, oxygen, carbon dioxide and waste between the blood stream and adjacent tissues across the capillary wall in the microvasculature of a mammalian subject, preferably a human subject, thus optimizing microvascular integrity and capillary structure, morphology, density and function, which comprises administering to said subject an effective amount of vitamin K.
A pharmaceutical or nutraceutical composition for use in the treatment of improving the exchange of nutrients, oxygen, carbon dioxide and waste between the blood stream and adjacent tissues across the capillary wall in the microvasculature of a mammalian subject, preferably a human subject, suffering from a disease selected from the group of diseases associated with impaired morphology or function of the microvasculature, in particular impaired capillary morphology or capillary dysfunction, renal disease, impaired vision or macula degeneration, left ventricular dysfunction, vascular dementia or cognitive decline, food malabsorption, COPD, pulmonary capillary dysfunction, impaired gas exchange efficiency, infertility or erectile dysfunction, diabetic necrosis and peripheral neuropathy, which comprises as active ingredient at least vitamin K.
Use of the plethysmographic acceleration pulse wave technique as a screening method for evaluating the risk of vitamin K insufficiency or the risk of developing vitamin K-insufficiency related diseases such as vascular calcification, diabetes, metabolic syndrome, pulmonary disease, chronic kidney disease, macula degeneration, osteoporosis and osteoarthritis.
Dependencies are inferred from the claim text.