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US 2018/0194715 A1Published application
Anticonvulsant compounds
AssigneeOwen-Barry Pharmaceuticals Inc.
InventorsMichael Poulter, TONY DURST
Life of this patent
Estimating the term…
Abstract
The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.
Claims32
A method for reducing the severity of convulsant activity, comprising administering to a subject a therapeutically effective amount of a compound represented by the following formula (I):
- wherein,
- R1=R2=CH3 or R1=H and R2=aryl, wherein aryl is a compound selected from the group consisting of:
- phenyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OH, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- 1- or 2-naphthyl;
- 2-, 3-, or 4-pyridyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- 2- or 3-furyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- or
- 2- or 3-thienyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- R3=H;
- C(O)R5, wherein R5=H, CH3, C2H5, CH(CH3)2, CHCH3CN, or aryl;
- C(O)—O—R6, wherein R6=pharmaceutically acceptable salts, H, C1 to C6 alkyl (straight chain or branched), CH2C6H5, or CH(CH2)n, and wherein n=2-5;
- C(O)NH2, C(O)NHR6 or C(O)NR7R8 wherein R7 and R8 independently=C1 to C6 alkyl (straight chain or branched), CH2C6H5, aryl, or R7 and R8 together=(CH2)n, and wherein n=3-5;
- OH, OCH3, or OCH2C6H5;
- S—CH3, S—C6H5, S(O)CH3, S(O)C6H5, SO2CH3, or SO2O6H5;
- NO2, NH2, NHR6, NR7R8, or pharmaceutically acceptable salts thereof;
- C≡C—C(O)CH3, C≡C—C(O)CH(CH3)2, C≡C—C(O)C2H5, C≡C—C(O)C6H5, C≡C—C(O)—OH, or pharmaceutically acceptable salts of C≡C—C(O)—O−;
- or
- CN;
- and
- R4=one or two compounds selected from the group consisting of H, CH3, OH, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, or CN
17 more elements
A method for reducing the severity of convulsant activity, comprising administering to a subject a therapeutically effective amount of a compound represented by the following formula (II):
- wherein,
- R1=R2=CH3 or R1=H and R2=aryl, wherein aryl is a compound selected from the group consisting of:
- phenyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OH, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- 1- or 2-naphthyl;
- 2-, 3-, or 4-pyridyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- 2- or 3-furyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- or
- 2- or 3-thienyl, unsubstituted or substituted with one or two compounds selected from the group consisting of CH3, OCH3, SO2CH3, SO2Ph, F, Cl, CF3, CN;
- R3=C1 to C6 alkyl (straight chain or branched), CH(CH2)n, wherein n=3-5, or aryl;
- CH2SC6H5, or CH2SO2C6H5;
- S—C6H5, S(O)C6H5, or SO2O6H5;
- CH═CHC(O)CH3, CH═CHC(O)C6H5, CH═CHC(O)—O—CH3, CH═CHC(O)—O—C2H5, CH═CHC(O)—O—CH(CH3)2, CH═CHC(O)—O—C4H9, or CH═CHC(O)—O—C6H5;
- CH═CHCN;
- or
- CH═CHSO2CH3, CH═CHSO2C6H5.
12 more elements
Dependencies are inferred from the claim text.