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US 2018/0193466 A1Published application
Starch-based microparticles for the release of agents disposed therein
AssigneePaladin Labs Inc.
InventorsMiloud Rahmouni, Mohamed N. Khalid, Vinayak Sant, Abdelaziz Tafer, Damon Smith
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Abstract
The invention provides starch-based microparticles with high loading capacity for the stabilization and/or controlled release of one or more agents, for example, a pharmaceutical, a taste masking agent, a flavoring agent, or a combination thereof, disposed within the microparticles, and to methods of making and using such microparticles.
Claims20
A method of producing hollow microparticles that stabilize and/or control the release of an agent disposed therein, the method comprising:
- (a) providing an aqueous dispersion comprising a mixture of from about 5% w/w to about 20% w/w of cross-linked high amylose starch and the agent to be released at a temperature ranging from room temperature to 60° C.;
- and
- (b) spray drying the dispersion of step (a) in a spray dryer to produce hollow microparticles having a mean diameter of from about 1 μm to about 200 μm, wherein the hollow microparticles stabilize or control the release of the agent disposed therein.
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Dependencies are inferred from the claim text.