Hand, foot, and mouth vaccines and methods of manufacture and use thereof
AssigneeTakeda Vaccines, Inc.
InventorsSubash Chandra DAS, Joseph David SANTANGELO, Dan Thomas STINCHCOMB, Jorge E. OSORIO
Life of this patent
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Abstract
The present disclosure relates to hand, foot, and mouth disease vaccines and immunogenic compositions having one or more antigens from at least one virus that causes hand, foot, and mouth disease in humans, and methods of manufacture, formulation, and testing, and uses thereof.
Claims16
1-19. (canceled)
A hand, foot, and mouth immunogenic composition comprising at least one intact, inactivated virus that causes hand, foot and mouth disease in humans and a detergent in an effective concentration, wherein:
- a) the at least one intact, inactivated virus was inactivated with formalin;
- b) the composition does not comprise an adjuvant, or comprises an aluminum salt adjuvant;
- or
- c) (a) and (b).
A method for inactivating a hand, foot, and mouth virus preparation, comprising:
- (a) isolating the hand, foot, and mouth virus preparation from one or more non-human cells, wherein the cells are used to produce the virus preparation;
- and
- (b) treating the virus preparation with an effective amount of formalin;
- and
- (c) purifying the virus preparation from the formalin,
- wherein the virus is EV71.
Dependencies are inferred from the claim text.