Back to results
US 2018/0186721 A1Published application
Oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis
AssigneeThe Governors of the University of Alberta
InventorsRylan LUNDGREN, Patrick MOON
Life of this patent
Estimating the term…
Abstract
Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.
Claims14
A method for arylation of an sp3 carbon nucleophile, comprising:
- reacting
- a. an arylboroxine or a compound Ar—B(OR)2, wherein R=alkyl;
- b. an sp3-carbon nucleophile,
- c. a copper based stoichiometric promoter, and
- d. triethylamine,
- the reaction taking place at a temperature of about room temperature to about 40° C., thereby creating a carbon-carbon bond.
3 more elements
A method for decarboxylative carbonyl α-arylation, comprising:
- reacting
- a. an aryl coupling partner,
- b. a carboxylic acid, and
- c. a copper based catalyst
- the reaction taking place at room temperature, exposed to air, thereby creating a carbon-carbon bond.
2 more elements
Dependencies are inferred from the claim text.