Glass derived nanoparticles for nerve tissue repair
AssigneesThe Curators of the University of Missouri, Saint Louis University, Washington University
InventorsDelbert E. Day, Ali Mohammadkah, Amy Beth Harkins, Laura Marquardt
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Abstract
A biocompatible, biodegradable composite material, and method of using nanoparticles formed within the composite material for nerve repair are disclosed. The nanoparticles may not be formed until the glass degrades upon contact with a fluid in vivo or in vitro.
Claims31
A biocompatible, biodegradable composite material for soft tissue repair, comprising:
- a matrix material;
- and
- a parent glass suspended within the matrix material, the parent glass comprising one or more dopants;
- wherein the parent glass releases a plurality of dopant based nanoparticles when in contact with a body fluid or simulated body fluid.
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A method of delivering nanoparticles to a region of interest, comprising:
- contacting a biocompatible, biodegradable composite material with a body fluid or simulated body fluid, the biocompatible, biodegradable composite material comprising:
- a matrix material;
- and
- a parent glass suspended within the matrix material, the parent glass comprising a dopant;
- and
- allowing the parent glass to react or degrade to form and release the nanoparticles.
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Dependencies are inferred from the claim text.