# US 2018/0177824 A1 · Compositions and methods for treating biofilms > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2018/0177824 A1 - Document ID: US20180177824A1 - Status: Published application - Kind: A1 - Application number: 15/852,622 - Filed: 2017-12-22 - Published: 2018-06-28 - Earliest claimed: 2012-02-17 - Assignees: SoftOx Solutions AS - Applicants: SoftOx Solutions AS - Inventors: Geir Hermod Almås - Web page: https://patentgrep.com/patent/US20180177824A1 ## CPC - A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61K 33/42: Phosphorus; Compounds thereof - C01B 11/04: Hypochlorous acid - A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C} ## Abstract Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release. ## Claims ### Claim 1 A composition comprising acetic acid and hypochlorous acid sufficient to treat a bacterial biofilm without harming surrounding tissue. ### Claim 2 (depends on 1) The composition of claim 1, wherein the acetic acid concentration is greater than about 0.25%. ### Claim 3 (depends on 2) The composition of claim 2, wherein the acetic acid concentration is greater than about 1.0%. ### Claim 4 (depends on 3) The composition of claim 3, wherein the acetic acid concentration is greater than about 2.0%. ### Claim 5 (depends on 1) The composition of claim 1, wherein the hypochlorous acid concentration is between 50 ppm and 500 ppm. ### Claim 6 (depends on 1) The composition of claim 1, wherein the hypochlorous acid concentration is approximately 200 ppm. ### Claim 7 (depends on 1) The composition of claim 1, wherein the acetic acid is present in a concentration sufficient to penetrate skin and treat a biofilm beneath the skin. ### Claim 8 (depends on 1) The composition of claim 1, wherein the hypochlorous acid is present in a concentration sufficient to modulate a toxic property of the acetic acid. ### Claim 9 (depends on 1) The composition of claim 1, wherein the acetic acid is present in a concentration sufficient to treat a biofilm on the skin or on teeth. ### Claim 10 (depends on 1) The composition of claim 1, wherein the composition is formulated in a gel, cream, ointment, or oil. ### Claim 11 (depends on 1) The composition of claim 1, wherein the acetic acid is encapsulated in a nanoparticle. ### Claim 12 A method for treating a bacterial infection in tissue, the method comprising providing to the tissue a composition comprising acetic acid and an amount of hypochlorous acid effective to modulate a toxic property of the acetic acid. ### Claim 13 (depends on 12) The method of claim 12, wherein the acetic acid is in a concentration sufficient to penetrate skin. ### Claim 14 (depends on 12) The method of claim 12, wherein said acetic acid is present in an amount from about 0.25% to about 2.0% and said hypochlorous acid is present in a concentration from about 50 ppm to about 500 ppm. ### Claim 15 (depends on 12) The method of claim 12, wherein the tissue is dental tissue, and wherein the hypochlorous acid concentration is about 200 ppm, and wherein the acetic acid concentration is between about 0.1% and about 0.5%. ### Claim 16 (depends on 12) The method of claim 12, wherein the tissue is skin, and wherein the hypochlorous acid concentration is about 200 ppm, and wherein the acetic acid concentration is between about 0.1% and about 0.5%. ### Claim 17 (depends on 12) The method of claim 12, wherein the tissue comprises a wound, and wherein the hypochlorous acid concentration is about 200 ppm, and wherein the acetic acid concentration is between about 1.0% and 2.0%. ### Claim 18 (depends on 12) The method of claim 12, wherein the tissue comprises a root of a tooth, and wherein the hypochlorous acid concentration is about 200 ppm, and wherein the acetic acid concentration is between about 1.0% and 2.0%.