# US 2018/0177823 A1 · Compositions and methods for aerodigestive treatment

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2018/0177823 A1
- Document ID: US20180177823A1
- Status: Published application
- Kind: A1
- Application number: 15/852,615
- Filed: 2017-12-22
- Published: 2018-06-28
- Earliest claimed: 2012-02-17
- Assignees: SoftOx Solutions AS
- Applicants: SoftOx Solutions AS
- Inventors: Geir Hermod Almås
- Web page: https://patentgrep.com/patent/US20180177823A1

## CPC

- A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- C01B 11/04: Hypochlorous acid
- A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}

## Abstract

Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including treating and regulating the aerodigestive tract. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different types of infections. Compositions may be provided in droplet, aerosol, gel, or powder form.

## Claims

### Claim 1

A composition for aerodigestive administration, the composition comprising hypochlorous acid, acetic acid and an acceptable carrier, adjuvant, or diluent in a substantially air-free container.

### Claim 2 (depends on 1)

The composition of claim 1, wherein said carrier is water.

### Claim 3 (depends on 1)

The composition of claim 1, wherein said carrier is an electrolyte composition.

### Claim 4 (depends on 1)

The composition of claim 1, wherein said composition is formulated so as to be aerosolized upon use.

### Claim 5 (depends on 4)

The composition of claim 4, wherein said composition is a nasal spray.

### Claim 6 (depends on 5)

The composition of claim 5, wherein said carrier is saline.

### Claim 7 (depends on 1)

The composition of claim 1, wherein the composition is substantially free of chlorine gas.

### Claim 8 (depends on 1)

The nasal spray composition of claim 1, wherein the composition is buffered and has a pH approximately equal to a pKa of acetic acid.

### Claim 9 (depends on 1)

The composition of claim 1, wherein said composition is formulated in an enema.

### Claim 10 (depends on 1)

The composition of claim 1, wherein said composition is formulated with an antibiotic.

### Claim 11 (depends on 1)

The composition of claim 1, wherein said composition is formulated with an antiviral.

### Claim 12 (depends on 1)

A method for treating a patient's aerodigestive tract, the method comprising applying a composition according to claim 1 to said aerodigestive tract.

### Claim 13 (depends on 12)

The method of claim 12, wherein said applying step comprises introducing a pharmaceutical dose to said patient.

### Claim 14 (depends on 1, 12)

The method of claim 12, wherein said applying step comprises oral introduction of the composition of claim 1.

### Claim 15 (depends on 1, 14)

The method of claim 14, wherein said oral introduction comprises a beverage comprising the composition of claim 1.

### Claim 16 (depends on 1, 12)

The method of claim 12, wherein said applying step comprises intranasal presentation of a composition of claim 1.

### Claim 17 (depends on 1)

The composition of claim 1, wherein the acetic acid is present in an amount from about 0.25% to about 2.0% and the hypochlorous acid is present in a concentration from about 50 ppm to about 500 ppm.

### Claim 19 (depends on 1)

The composition of claim 1, wherein the hypochlorous acid is present in a concentration sufficient to modulate a toxic property of the acetic acid.