# US 2018/0177822 A1 · Acetic acid and hypochlorous acid compositions for treatment of skin trauma > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2018/0177822 A1 - Document ID: US20180177822A1 - Status: Published application - Kind: A1 - Application number: 15/852,603 - Filed: 2017-12-22 - Published: 2018-06-28 - Earliest claimed: 2012-02-17 - Assignees: SoftOx Solutions AS - Applicants: SoftOx Solutions AS - Inventors: Geir Hermod Almås - Web page: https://patentgrep.com/patent/US20180177822A1 ## CPC - A61K 33/20: Elemental chlorine; Inorganic compounds releasing chlorine - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61K 33/42: Phosphorus; Compounds thereof - C01B 11/04: Hypochlorous acid - A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C} ## Abstract Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating biofilms in or on tissue, including biofilms related to wounds or other skin trauma. The compositions are useful for treating a variety of types of tissue, both on the surface on beneath the surface of tissue. Compositions are provided having various concentrations for different tissue types and infection levels. Compositions may be provided in gel form, and may include nanoparticle encapsulated molecules for controlled release. ## Claims ### Claim 1 A method for treating tissue trauma, the method comprising providing to a tissue subject to trauma a composition comprising hypochlorous acid and acetic acid. ### Claim 2 (depends on 1) The method of claim 1, wherein the tissue is within a surgical operating field. ### Claim 3 (depends on 1) The method of claim 1, wherein the composition is provided to the tissue before making a surgical incision. ### Claim 4 (depends on 1) The method of claim 1, wherein the composition is provided to the tissue after making a surgical incision. ### Claim 5 (depends on 1) The method of claim 1, further comprising debriding the tissue with the composition. ### Claim 6 (depends on 1) The method of claim 1, wherein the tissue comprises skin. ### Claim 7 (depends on 1) The method of claim 1, wherein the hypochlorous acid is present in a concentration sufficient to modulate a toxic property of the acetic acid. ### Claim 8 (depends on 1) The method of claim 1, wherein the acetic acid concentration is greater than about 1.0%. ### Claim 9 (depends on 1) The method of claim 1, wherein the acetic acid concentration is greater than about 2.0%. ### Claim 10 (depends on 1) The method of claim 1, wherein the hypochlorous acid concentration is between 50 ppm and 500 ppm. ### Claim 11 (depends on 1) The method of claim 1, wherein the hypochlorous acid concentration is approximately 200 ppm. ### Claim 12 (depends on 1) The method of claim 1, wherein the composition is buffered and has a pH approximately equal to a pKa of acetic acid. ### Claim 13 (depends on 1) The method of claim 1, wherein the composition comprises a liquid, powder, lotion, cream, gel, oil, ointment, gel, solid, semi-solid, or aerosol spray. ### Claim 14 (depends on 1) The method of claim 1, wherein providing comprises spraying a mist onto the tissue, contacting the tissue with a wipe comprising the composition, contacting the tissue with a cream or lotion comprising the composition, soaking the tissue in the composition, submerging the tissue in the composition, or washing the tissue with the composition. ### Claim 15 A method for treating a biofilm in a wound, the method comprising providing to the wound a composition comprising hypochlorous acid and acetic acid. ### Claim 16 (depends on 15) The method of claim 15, wherein the wound comprises a bedsore, a chronic wound, a burn, a pressure wound, a diabetes-related wound, or a surgical site. ### Claim 17 (depends on 15) The method of claim 15, further comprising debriding the wound with the composition. ### Claim 18 (depends on 15) The method of claim 15, wherein the composition is substantially free of chlorine gas. ### Claim 19 (depends on 15) The method of claim 15, wherein the composition is buffered. ### Claim 20 (depends on 15) The method of claim 15, wherein the composition is buffered and has a pH approximately equal to a pKa of acetic acid. ### Claim 21 (depends on 15) The method of claim 15, wherein the composition comprises a liquid, powder, lotion, cream, gel, oil, ointment, gel, solid, semi-solid, or aerosol spray. ### Claim 22 (depends on 15) The method of claim 15, wherein providing comprises spraying a mist onto the tissue, contacting the tissue with a wipe comprising the composition, contacting the tissue with a cream or lotion comprising the composition, soaking the tissue in the composition, submerging the tissue in the composition, or washing the tissue with the composition.