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US 2018/0170970 A1Published application
Viral chimeric particle of potato virus x and use thereof for in vitro diagnosis of sjögren syndrome
AssigneesENEA—Agenzia Nazionale per le Nuove Tecnologie, l'Energia e lo Sviluppo Economico Sostenibile, Universita' Degli Studi Di Verona
InventorsChiara LICO, Selene BASCHIERI, Eugenio BENVENUTO, Linda AVESANI, Elisa TINAZZI, Elena BARTOLONI BOCCI, Mario PEZZOTTI, Claudio LUNARDI
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Abstract
The present invention relates to a chimeric virus particle of potato virus X, said particle having, as a capsid protein, a fusion protein containing a capsid protein and an antigenic determinant of lipocalin, and the use thereof in the in vitro diagnosis of Sjögren's Syndrome using the ELISA method.
Claims24
1) A fusion protein comprising or consisting of:
- an amino-terminal portion consisting of a peptide sequence comprising or consisting of an antigenic determinant of lipocalin;
- and
- a carboxy-terminal portion consisting of a peptide sequence comprising or consisting of the capsid protein of a PVX virus, said capsid protein being intact or deleted in the 5′ portion of the gene which encodes the wild-type capsid protein, said amino-terminal portion being fused to said carboxy-terminal portion in such a way that said antigenic determinant is in frame with said capsid protein.
Dependencies are inferred from the claim text.