Multifunctional cytoprotectant for treatment of pathogenic processes mediated by oxidative stress and toxic electrophiles
AssigneeMontefiore Medical Center
InventorsRichard M. LoPachin, Terrence Gavin
Life of this patent
Estimating the term…
Abstract
Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.
Claims30
A method of treating a toxicity due to a therapeutic agent or an agent that causes oxidative cellular damage in a subject receiving the agent comprising administering to the subject a compound of formula (I) in an amount effective to reduce toxicity due to the agent, wherein the compound has the structure:
- wherein
- R1 and R3 are independently alkyl, alkenyl, aryl, aralkyl, cyclic, heteroaryl, heteroaralkyl or heterocyclic;
- R2 is OH, NH2, NHCOR3, N-alkyl, N,N-dialkyl, cyclic N,N-dialkyl, SH, S-alkyl, S-aryl, aryl, heteroaryl, or NR4R5;
- and
- R4 and R5 are independently alkyl or N-alkyl, and R4 and R5 can form a ring with each other, and any ring so formed may be aromatic or heteroaromatic, and any ring so formed may contain one or more N, O and/or S atoms;
- wherein any aryl, aralkyl, cyclic, heteroaryl, heteroaralkyl, heterocyclic or ring can be independently substituted with ═O, OH, halogen, CH3 or NH2;
- wherein any alkyl can independently be branched or unbranched;
- or a tautomer thereof;
- or a geometric or optical isomer thereof;
- or racemate thereof;
- or a pharmaceutically acceptable salt thereof.
11-15. (canceled)
A method of preventing or treating liver ischemia-reperfusion injury in a subject comprising administering to the subject a compound of formula (I) in an amount effective to prevent or reduce liver ischemia-reperfusion injury, wherein the compound has the structure:
- wherein
- R1 and R3 are independently alkyl, alkenyl, aryl, aralkyl, cyclic, heteroaryl, heteroaralkyl or heterocyclic;
- R2 is OH, NH2, NHCOR3, N-alkyl, N,N-dialkyl, cyclic N,N-dialkyl, SH, S-alkyl, S-aryl, aryl, heteroaryl, or NR4R5;
- and
- R4 and R5 are independently alkyl or N-alkyl, and R4 and R5 can form a ring with each other, and any ring so formed may be aromatic or heteroaromatic, and any ring so formed may contain one or more N, O and/or S atoms;
- wherein any aryl, aralkyl, cyclic, heteroaryl, heteroaralkyl, heterocyclic or ring can be independently substituted with ═O, OH, halogen, CH3 or NH2;
- wherein any alkyl can independently be branched or unbranched;
- or a tautomer thereof;
- or a geometric or optical isomer thereof;
- or racemate thereof;
- or a pharmaceutically acceptable salt thereof.
17-42. (canceled)
(canceled)
(canceled)
A compound having the structure:
- wherein
- R1 and R3 are independently alkyl, alkenyl, aryl, aralkyl, cyclic, heteroaryl, heteroaralkyl or heterocyclic;
- R2 is NH2, NHCOR3, N-alkyl, N,N-dialkyl, cyclic N,N-dialkyl, SH, S-alkyl, S-aryl, aryl, heteroaryl, or NR4R5;
- and
- R4 and R5 are independently alkyl or N-alkyl, and R4 and R5 can form a ring with each other, and any ring so formed may be aromatic or heteroaromatic, and any ring so formed may contain one or more N, O and/or S atoms;
- wherein any aryl, aralkyl, cyclic, heteroaryl, heteroaralkyl, heterocyclic or ring can be independently substituted with ═O, OH, halogen, CH3 or NH2;
- wherein any alkyl can independently be branched or unbranched;
- or a tautomer thereof;
- or a geometric or optical isomer thereof;
- or racemate thereof;
- or a pharmaceutically acceptable salt thereof.
49-52. (canceled)
Dependencies are inferred from the claim text.