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US 2018/0155386 A1Published application
Progesterone antagonists
AssigneeEvestra, Inc.
InventorsKlaus Nickisch, Kesavaram Narkunan, Baishakhi Debnath, Bindu Santhamma
Life of this patent
Estimating the term…
Abstract
Described herein are compounds which either act as pure antiprogestins or as antiprogestins with partial agonistic activity and methods of treating cancer using such compounds.
Claims9
1-9. (canceled)
A method of treating cancer in a subject comprising administering to a subject a medicament comprising an effective amount of a compound having the structure of formula (I):
- In which
- X is O;
- R1, R2, R3, and R4 is a hydrogen atom;
- R5 is a radical Y or an aryl radical that is optionally substituted with Y,
- Y is —C1-C10 alkylacyl;
- C3-C10 cycloalkyl;
- C1-C10 alkanoyloxy;
- or a five or six membered heterocyclic radical containing up to three heteroatoms;
- R6 is —OH, —OR8, —OC(O)R8;
- R7 is a radical of formula CnFmHo where n is 3, m is either 2 or 3;
- and m+o is 5;
- and
- R8 is H, alkyl, alkyloxy, or aryl.
10 more elements
(canceled)
13-14. (canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.