# US 2018/0154065 A1 · System and Method for Removing Fat from Salvaged Blood

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- Number: US 2018/0154065 A1
- Document ID: US20180154065A1
- Status: Published application
- Kind: A1
- Application number: 15/577,005
- Filed: 2016-07-13
- Published: 2018-06-07
- Earliest claimed: 2015-07-13
- Assignees: Haemonetics Corporation
- Applicants: Haemonetics Corporation
- Inventors: Seth Kasper; Jordan Smelker; Samuel Vaughan
- Web page: https://patentgrep.com/patent/US20180154065A1

## CPC

- A61M 1/3692: {Washing or rinsing blood or blood constituents}
- A61M 1/0209: {Multiple bag systems for separating or storing blood components}
- A61M 1/0281: {Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing}
- A61M 1/3693: {using separation based on different densities of components, e.g. centrifuging}
- A61M 1/38: Removing constituents from donor blood and {storing or} returning remainder to body {, e.g. for transfusion}
- A61M 2202/0021: removed from and reintroduced into the body, e.g. after treatment
- A61M 2202/0085: product washed out
- A61M 2202/0092: starting product created by centrifuging
- A61M 2202/0413: Blood
- A61M 2202/08: Lipoids
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A method for removing fat from salvaged blood includes transferring salvaged blood from a reservoir to a blood component separation device, and separating the blood into a plurality of blood components. The method may then transfer a volume of unwashed blood components from the blood component separation device back toward the reservoir, and recentrifuge the blood components remaining within the blood component separation device. After re-centrifuging, the method transfers additional salvaged blood from the reservoir to the blood component separation device to refill the blood component separation device. The method may then wash the components within the bowl by introducing wash solution into the blood component separation device. The wash solution displaces a volume of fat from the blood component separation device and into a waste container. The method may then empty the washed blood components within the blood component separation device to a product container.

## Claims

### Claim 1

A method for removing fat from salvaged blood, the method comprising:
(a) transferring salvaged blood from a reservoir to a blood component separation device, the salvaged blood filling the blood component separation device;
(b) separating the salvaged blood into a plurality of blood components;
(c) transferring a volume of unwashed blood components from the blood component separation device back toward the reservoir;
(d) re-centrifuging the blood components remaining within the blood component separation device;
(e) transferring additional salvaged blood from the reservoir to the blood component separation device, thereby refilling the blood component separation device;
(f) introducing wash solution into the blood component separation device, the wash solution displacing a volume of fat from the blood component separation device into a waste container; and
(g) emptying the washed blood components within the blood component separation device to a product container.

### Claim 2 (depends on 1)

A method according to claim 1, further comprising:
transferring, prior to emptying the washed blood components to the product container, a volume of washed blood components from the blood component separation device to the product container;
re-centrifuging the washed blood components remaining within the blood component separation device;
returning the volume of washed blood components from the product container to the blood component separation device, thereby refilling the blood component separation device; and
introducing additional wash solution into the blood component separation device, the additional wash solution displacing a second volume of fat from the blood component separation device into a waste container.

### Claim 3 (depends on 2)

A method according to claim 2, wherein the blood component separation device is a 70 mL centrifuge bowl, the volume of unwashed blood component transferred toward the reservoir being between 20 and 30 mL.

### Claim 4 (depends on 3)

A method according to claim 3, wherein the volume of additional salvaged blood transferred in step (e) is equivalent to the volume of unwashed blood component transferred to the reservoir.

### Claim 5 (depends on 3)

A method according to claim 3, wherein the volume of washed blood components transferred to the product container is between 20 and 30 mL.

### Claim 6 (depends on 3)

A method according to claim 3, wherein introducing additional wash solution into the blood component separation device includes introducing 50 ml of wash solution.

### Claim 7 (depends on 2)

A method according to claim 2, wherein the blood component separation device is a 125 mL centrifuge bowl, the volume of unwashed blood component transferred toward the reservoir being between 20 and 30 mL.

### Claim 8 (depends on 7)

A method according to claim 7, wherein the volume of additional salvaged blood transferred in step (e) is equivalent to the volume of unwashed blood component transferred toward the reservoir.

### Claim 9 (depends on 7)

A method according to claim 7, wherein the volume of washed blood components transferred to the product container is between 80 and 100 mL.

### Claim 10 (depends on 7)

A method according to claim 7, wherein introducing additional wash solution into the blood component separation device includes introducing 100 ml of wash solution.

### Claim 11 (depends on 2)

A method according to claim 2, wherein the blood component separation device is a 225 mL centrifuge bowl, the volume of unwashed blood component transferred toward the reservoir being between 20 and 30 mL.

### Claim 12 (depends on 11)

A method according to claim 11, wherein the volume of additional salvaged blood transferred in step (e) is equivalent to the volume of unwashed blood component transferred toward the reservoir.

### Claim 13 (depends on 11)

A method according to claim 11, wherein the volume of washed blood components transferred to the product container is between 160 and 180 mL.

### Claim 14 (depends on 11)

A method according to claim 11, wherein introducing additional wash solution into the blood component separation device includes introducing 100 ml of wash solution.

### Claim 15 (depends on 1)

A method according to claim 1, further comprising:
monitoring the separation of salvaged blood within the blood component separation device to detect when the blood component separation device is full; and
stopping the blood component separation device when the blood component separation device is full and prior to step (c).

### Claim 16 (depends on 1)

A method according to claim 1, wherein the volume of unwashed blood components transferred to the reservoir includes red blood cells.

### Claim 17 (depends on 1)

A method according to claim 1, wherein re-centrifuging in step (d) causes fat within the blood component separation device to pass through a red blood cell product within the blood component separation device and toward an outlet of the blood component separation device.

### Claim 18 (depends on 1)

A method according to claim 1, further comprising stopping the blood component separation device prior to step (c).

### Claim 19 (depends on 1)

A method according to claim 1, wherein at least a portion of the volume of unwashed blood components transferred back toward the reservoir remains within a reservoir line fluidly connecting the reservoir and the blood component separation device.

### Claim 20 (depends on 19)

A method according to claim 19, wherein the additional salvaged blood includes the volume of unwashed blood components transferred back toward the reservoir.

### Claim 21

A method for removing fat from salvaged blood, the method comprising:
(a) transferring salvaged blood from a reservoir to a blood component separation device, the salvaged blood filling the blood component separation device;
(b) separating the salvaged blood into a plurality of blood components;
(c) introducing wash solution into the blood component separation device, the wash solution displacing a volume of unwanted components from the blood component separation device into a waste container;
(d) transferring, a volume of washed blood components from the blood component separation device to a product container;
(e) re-centrifuging the washed blood components remaining within the blood component separation device;
(f) returning the volume of washed blood components from the product container to the blood component separation device, thereby refilling the blood component separation device;
(g) introducing additional wash solution into the blood component separation device, the additional wash solution displacing a volume of fat from the blood component separation device into a waste container; and
(h) emptying the washed blood components within the blood component separation device to a product container.

### Claim 22 (depends on 21)

A method according to claim 21, further comprising stopping the blood component separation device prior to step (d).

### Claim 23 (depends on 21)

A method according to claim 21, wherein the blood component separation device is at least one selected from the group consisting of a 70 mL centrifuge bowl, a 125 mL centrifuge bowl, and a 225 mL centrifuge bowl.

### Claim 24 (depends on 21)

A method according to claim 21, wherein the volume of washed blood components transferred to the product container is between 20 and 30 mL.

### Claim 25 (depends on 21)

A method according to claim 21, wherein the blood component separation device is a 70 mL centrifuge bowl and introducing additional wash solution into the blood component separation device includes introducing 50 ml of wash solution.

### Claim 26 (depends on 21)

A method according to claim 21, wherein the blood component separation device is a 125 mL centrifuge bowl and introducing additional wash solution into the blood component separation device includes introducing 100 ml of wash solution.

### Claim 27 (depends on 21)

A method according to claim 21, wherein the blood component separation device is a 225 mL centrifuge bowl and introducing additional wash solution into the blood component separation device includes introducing 100 ml of wash solution.

### Claim 28 (depends on 21)

A method according to claim 21, wherein the volume of washed blood components transferred to the product container is between 80 and 100 mL.

### Claim 29 (depends on 21)

A method according to claim 21, wherein the volume of washed blood components transferred to the product container is between 160 and 180 mL.

### Claim 30

A system for washing fat from salvaged blood, the system comprising:
a reservoir configured to collect salvaged blood from a patient;
a rotatable centrifuge bowl fluidly connected to the reservoir and configured to separate the salvaged blood into a plurality of blood components;
a product container fluidly connected to the rotatable centrifuge bowl and configured to collect a washed blood component;
a waste container fluidly connected to an outlet of the rotatable centrifuge bowl and configured to collect a waste product from the centrifuge bowl;
a pump configured to control the flow of fluid through the system; and
a controller configured to control the operation of the pump and centrifuge bowl to transfer a first volume of unwashed blood components from the centrifuge bowl back toward the reservoir, re-centrifuge the blood components remaining within the centrifuge bowl, refill the centrifuge bowl with salvaged blood from the reservoir, and introduce wash solution into the centrifuge bowl, the wash solution displacing a volume of fat from the centrifuge bowl into the waste container.

### Claim 31 (depends on 30)

A system according to claim 30, wherein the controller is further configured to empty the washed blood components within the centrifuge bowl to the product container.

### Claim 32 (depends on 30)

A system according to claim 30, wherein the controller is configured to control the pump and centrifuge bowl to transfer a volume of washed blood components from the blood component separation device to the product container, re-centrifuge the washed blood components remaining within the blood component separation device, and return the volume of washed blood components from the product container to the blood component separation device, thereby refilling the blood component separation device.

### Claim 33 (depends on 32)

A system according to claim 32, wherein the controller is further configured to control the pump to introduce additional wash solution into the centrifuge bowl, the additional wash solution displacing a second volume of fat from the centrifuge bowl into the waste container.

### Claim 34 (depends on 30)

A system according to claim 30, wherein the centrifuge bowl is at least one selected from the group consisting of a 70 mL centrifuge bowl, a 125 mL centrifuge bowl, and a 225 mL centrifuge bowl.

### Claim 35 (depends on 30)

A system according to claim 30 further comprising an optical sensor configured to monitor the separation of salvaged blood within the centrifuge bowl and detect when the centrifuge bowl is full.

### Claim 36 (depends on 30)

A system according to claim 30, wherein the first volume of unwashed blood components includes red blood cells.

### Claim 37

A method for removing fat from salvaged blood, the method comprising:
(a) transferring salvaged blood from a reservoir to a blood component separation device, the salvaged blood filling the blood component separation device;
(b) separating the salvaged blood into a plurality of blood components;
(c) transferring a volume of unwashed blood components from the blood component separation device back to a reservoir line fluidly connecting the reservoir and the blood component separation device;
(d) re-centrifuging the blood components remaining within the blood component separation device;
(e) returning the volume of unwashed blood components from the reservoir line to the blood component separation device, thereby refilling the blood component separation device;
(f) introducing wash solution into the blood component separation device, the wash solution displacing a volume of fat from the blood component separation device into a waste container; and
(g) emptying the washed blood components within the blood component separation device to a product container.

### Claim 38 (depends on 37)

A method according to claim 37, further comprising:
transferring, prior to emptying the washed blood components to the product container, a volume of washed blood components from the blood component separation device to the product container;
re-centrifuging the washed blood components remaining within the blood component separation device;
returning the volume of washed blood components from the product container to the blood component separation device, thereby refilling the blood component separation device; and
introducing additional wash solution into the blood component separation device, the additional wash solution displacing a second volume of fat from the blood component separation device into a waste container.

### Claim 39 (depends on 38)

A method according to claim 38, wherein the blood component separation device is a 70 mL centrifuge bowl, the volume of unwashed blood component transferred to the reservoir line being between 20 and 30 mL.

### Claim 40 (depends on 39)

A method according to claim 39, wherein the volume of washed blood components transferred to the product container is between 20 and 30 mL.

### Claim 41 (depends on 39)

A method according to claim 39, wherein introducing additional wash solution into the blood component separation device includes introducing 50 ml of wash solution.

### Claim 42 (depends on 38)

A method according to claim 38, wherein the blood component separation device is a 125 mL centrifuge bowl, the volume of unwashed blood component transferred to the reservoir line being between 20 and 30 mL.

### Claim 43 (depends on 42)

A method according to claim 42, wherein the volume of washed blood components transferred to the product container is between 80 and 100 mL.

### Claim 44 (depends on 42)

A method according to claim 42, wherein introducing additional wash solution into the blood component separation device includes introducing 100 ml of wash solution.

### Claim 45 (depends on 38)

A method according to claim 38, wherein the blood component separation device is a 225 mL centrifuge bowl, the volume of unwashed blood component transferred to the reservoir line being between 20 and 30 mL.

### Claim 46 (depends on 45)

A method according to claim 45, wherein the volume of washed blood components transferred to the product container is between 160 and 180 mL.

### Claim 47 (depends on 45)

A method according to claim 45, wherein introducing additional wash solution into the blood component separation device includes introducing 100 ml of wash solution.

### Claim 48 (depends on 37)

A method according to claim 37, further comprising:
monitoring the separation of salvaged blood within the blood component separation device to detect when the blood component separation device is full; and
stopping the blood component separation device when the blood component separation device is full and prior to step (c).

### Claim 49 (depends on 37)

A method according to claim 37, wherein the volume of unwashed blood components transferred to the reservoir line includes red blood cells.

### Claim 50 (depends on 37)

A method according to claim 37, wherein the volume of unwashed blood components transferred to the reservoir line includes red blood cells suspended in plasma.

### Claim 51 (depends on 37)

A method according to claim 37, wherein re-centrifuging in step (d) causes fat within the blood component separation device to pass through a red blood cell product within the blood component separation device and toward an outlet of the blood component separation device.

### Claim 52 (depends on 37)

A method according to claim 37, further comprising stopping the blood component separation device prior to step (c).
